Origin, function and role in the development of skin diseases CLA+T-lymphocytes

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Abstract

The idea of CLA+T-lymphocytes, which are a special subpopulation of cells with a tropic to the skin, is given. The issues of maturation, migration and functional features of CLA+T-cells are considered. Special attention is paid to the different phenotype of memory T-cells. Modern data concerning the role of CLA+T-cells in the pathogenesis of autoimmune and allergic dermatoses, as well as malignant skin tumors are also presented. The conclusion about the necessity of further study of CLA +T-lymphocytes for detailed understanding of pathogenesis and search of variants of targeted therapy in psoriasis, atopic dermatitis, skin lymphomas and other skin diseases is made.

About the authors

A. V. Patrushev

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Author for correspondence.
Email: alexpat2@yandex.ru

Aleksandr V. Patrushev — Cand. Sci. (Medicine), Research Assistant, Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

A. V. Samtsov

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: avsamtsov@mail.ru

Aleksey V. Samtsov — Dr. Sci. (Medicine), Prof., Departmental Head, Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

V. Yu. Nikitin

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: vladimiryn@mail.ru

Vladimir Yu. Nikitin — Dr. Sci. (Medicine), Head of the Immunological Laboratory, Centre for Clinical Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

A. М. Ivanov

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: iamvma@mail.ru

Andrey M. Ivanov — Dr. Sci. (Medicine), Corresponding Member of the Russian Academy of Sciences, Prof., Head of the Department of Clinical Biochemistry and Laboratory Diagnostics, S. M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation

Academician Lebedev str., 6, Saint Petersburg, 194044


Russian Federation

O. Р. Gumilevskaya

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: ogum@mail.ru

Oksana P. Gumilevskaya — Dr. Sci. (Medicine), Ass. Prof., Head of the Centre for Clinical Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

A. V. Sukharev

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: asoukharev@mail.ru

Aleksey V. Sukharev — Dr. Sci. (Medicine), Prof., Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

I. A. Sukhina

S. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian Federation

Email: kinya2000@mail.ru

Irina A. Sukhina — Cand. Sci. (Biology), Lecturer, Department of Clinical Biochemistry and Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Russian Federation

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Copyright (c) 2018 Patrushev A.V., Samtsov A.V., Nikitin V.Y., Ivanov A.М., Gumilevskaya O.Р., Sukharev A.V., Sukhina I.A.

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