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Naftifine hydrochloride (NH) in the treatment of pityriasis versicolor
- Authors: Kotrekhova L.P.1, Vashkevich A.A.1, Tsurupa E.N.1, Reztsova P.A.1
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Affiliations:
- “North-Western State Medical University named after I.I. Mechnikov”
- Issue: Vol 92, No 2 (2016)
- Pages: 103-109
- Section: DRUG TREATMENT IN DERMATOVENEROLOGY
- URL: https://vestnikdv.ru/jour/article/view/232
- DOI: https://doi.org/10.25208/0042-4609-2016-92-2-103-109
- ID: 232
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Abstract
Introduction & objectives: The purpose of this study was to demonstrate the efficacy comparability of 1% NH lotion vs. of 1% NH cream (exoderil, Sandoz) in the treatment of pityriasis versicolor. Material & methods. 71 patients with pityriasis versicolor were randomly allocated either to receive NH lotion once daily (NH lotion group (п = 35, 38.6 years (95% CI [33,7, 43.5]) or NH cream once daily (NH cream group (п = 36, 40.8 years (95% CI [36,6, 45.0]) for 14 days. Mycological evaluations (microscopy and culture) were performed at weeks 2 and 3, inflammation symptoms evaluations were scored at day 3, weeks 2 and 3 after start of the therapy. Overall cure rates assessment included results of mycological, clinical outcomes and safety evaluation. Results. There was no difference between groups in mycological cure rates (94% vs 92%) and inflammation regression (97% vs 97%). Overall cure rate was 91% and 92% of patients in NH lotion and NH cream groups respectively (p = 0,97). Conclusion. 1% NH lotion and 1% NH cream are effective in the treatment of pityriasis versicolor.
About the authors
L. P. Kotrekhova
“North-Western State Medical University named after I.I. Mechnikov”
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. A. Vashkevich
“North-Western State Medical University named after I.I. Mechnikov”
Email: noemail@neicon.ru
Russian Federation
E. N. Tsurupa
“North-Western State Medical University named after I.I. Mechnikov”
Email: noemail@neicon.ru
Russian Federation
P. A. Reztsova
“North-Western State Medical University named after I.I. Mechnikov”
Email: noemail@neicon.ru
Russian Federation
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