Vol 89, No 2 (2013)

The authors present literature data related to the epidemiology, etiology, pathogenesis and clinical course of basalioma. The key classifications are given. As many as 62 references are reviewed.

Goal. To develop a personified approach to the management of men with the urogenital chlamydia infection based on studying the molecular and genetic risk factors of the development of complications. Materials and methods. Patients with the urogenital chlamydia infection (20 men with the urogenital chlamydia infection of the lower urogenital tract and 20 men with complicated forms of the urogenital chlamydia infection) and men without any clinical or laboratory signs of STDs and inflammatory diseases of the urogenital tract. The following methods were used in the study: anamnestic, clinical, instrumental (transrectal ultrasonography) and laboratory (microscopic, bacteriological, molecular and biological (PCR, SNaPshot)). Results. According to the study results, the share of cases of ureteritis caused by C. trachomatis amounted to 10.5% of the total share of cases of ureteritis and 13.0% of cases of non-gonococcal ureteritis. The percentage of complicated urogenital diseases caused by C. trachomatis amounted to 34.5% of the total share of complicated forms and 35.7% of noncomplicated forms of the non-gonococcal origin. Subjective clinical signs of complicated forms of the chlamydia infection did not have any reliable distinctions from those observed in case of non-complicated forms of the disease; the infectious process caused by C. trachomatis was characterized by the absence of leukocytosis in the urethra in 30.0% of men with both non-complicated and complicated forms of the disease. The study of the polymorphism of cytokine genes revealed that the CC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the complicated course of urogenital chlamydiosis in men while the GC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the non-complicated course of urogenital chlamydiosis in men. Based on these results, the authors developed an algorithm for a differential approach to the management of patients suffering from chlamydia infection. Conclusion. A differential approach to the management of men with the urogenital chlamydia infection depending on the molecular predictor of the complicated course of the disease was developed.

Goal of the study. To study the qualitative and quantitative composition of the vaginal microcenosis in women of childbearing potential with vulvovaginitis and determine the sensitivity indices of opportunistic microorganisms being etiological agents of vulvovaginitis concerning antibacterial drugs. Materials and methods. Samples of the vaginal fluid obtained from 264 women (198 patients with clinical and laboratory signs of vulvovaginitis and 66 clinically healthy women) as well as 190 isolates of opportunistic microbial agents were analyzed with the use of microscopic and cultural methods as well as polymerase chain reaction. Results. The authors determined the composition of the vaginal microbiocenosis in women suffering from vulvovaginitis characterized by the prevalence of Corynebacterium spp., E. coli, E. faecalis, S. saprophiticus, K. pneumoniae, S. anginosus, S. agalactiae in the amount exceeding 10 2—10 4 CFU/ml and in associations of four or more microorganisms. The authors revealed that opportunistic microorganisms had the highest sensitivity to amoxicillin/clavulanic acid, nitrofuran and ceftriaxone.

The authors describe a clinical observation of quite a rare neoplasm such as back skin leiomyoma in a female patient aged 56. They describe the clinical picture, differential diagnostics and pathohistological picture of the disease. The pain syndrome was arrested due to the treatment with calcium channel blockers in a combination with alpha-blockers.

Clobetasol propionate is a potent topical corticosteroid that is widely used for the treatment of scalp psoriasis today. The review provides data obtained as a result of numerous clinical studies meeting the requirements of evidence-based medicine concerning the efficacy and safety of a new drug form — Clobetasol Propionate 0.05% Shampoo. Its short-term administration arrests exacerbations of dermatosis while a long-term proactive therapy prevents the development of new psoriatic eruptions on the sculp. Such issues as cosmetic acceptability and compliance of Clobetasol Propionate Shampoo for patients suffering from the scalp psoriasis are discussed.

The article discloses archival materials describing the establishment of the Dermatovenerology Institute and Dispensary in the Stavropol Territory as well as their growth and development. The article includes documents as of the 1920s and present-day photos.