Vol 92, No 2 (2016)

Reasonable selection of a topical therapy for different forms of acne
Kokhan M.M., Keniksfest Y.V., Polishchuk A.I.

Abstract

Modern data of the acne pathogenesis, including the role of Propionibacterium acnes in the early stages of the acne formation and their provocative role in the development of the inflammatory process are presented. Priority importance of topical retinoids and combination products containing fixed combinations adapalene with benzoyl peroxide or antibiotic clindamycin in the acne treatment are shown. There are presented the facts of the effectiveness of Clenzit gel (adapalene 0.1%) and Clenzit-C (adapalene 0.1% and clindamycin phosphate 1.0%) and an algorithm for the choice of drug depending on clinical and morphological features of the skin process that allows to optimize the treatment of patients with various forms of acne.
Vestnik dermatologii i venerologii. 2016;92(2):81-86
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Particular features of the immune status in microbial eczema and erysipelas patients: a therapeutic method
Zinatulina G.M., Fayzullina E.V., Fazyilov V.H., Vasilkin D.A.

Abstract

Goal of the study. To study particular features of the immune status in microbial eczema and erysipelas patients in the process of a complex immune modulating therapy with Xymedone®. Materials and methods. the study involved 45 microbial eczema patients and 31 patients with a combined form of microbial eczema and erysipelas (the study group) and healthy subjects (60 and 50 subjects). All of the subjects underwent immunology examinations of their cell and humoral immunity prior to and after the pathogenetic treatment with Xymedone®. The traditional therapy of a combined course of microbial eczema and erysipelas comprised the following basic treatment: third-generation cephalosporins (ceftriaxone): 1.0 g a day for 10 days; second-generation antihistamine drugs (peroral loratadine 10 mg once a day for 10 days) and ascorbic acid 0.5 g a day for 14 days. topical treatment comprised antiseptic agents (furacilin solution 1:1000) at the acute stage, emulsions and creams (depending on the disease stage): topical mometasone furoate 0.1% twice a day for 14 days. The patients receiving Xymedone were treated in the dose of 0.25 g, one pill tree times a day for 14 days. The patients underwent an immunology study using the Sysmex Corporation XT2000 automated analyzer at the CityLab laboratory centers in the city of Kazan. Key findings. Prior to the pathogenic therapy, a high level of CD4 (T helpers) and reduced level of the immunoregulatory index (T helpers to T suppressors ratio) (IRI) was revealed in the microbial eczema patients. Ig А and Ig G concentrations were reliably increased. According to a study of immunology indices, the pathogenic therapy using Xymedone® normalized the number of peripheral blood leucocytes and reliably increased the IRI (p < 0.001) in 45 microbial eczema patients. Prior to the pathogenic therapy, a reduced level of CD3 and CD4 cells was revealed in patients with a combined form of microbial eczema and erysipelas; the levels of CD8 and NK cells (CD16) were also reduced. Ig А, Ig M and IgG concentrations were reliably reduced. According to a study of immunology indices, the pathogenic therapy using Xymedone® increased the concentration of CD3 and CD4 cells. Conclusion. Xymedone®, an immune modulating drug, administered as a part of a combination therapy of microbial eczema patients and patients with a combined form of microbial eczema and erysipelas is a form of supplementary pathogenic I therapy; the treatment improved the cellular and humoral immunity indices.
Vestnik dermatologii i venerologii. 2016;92(2):87-95
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Atopic dermatitis in children: prospects of using innovation products as an external therapy
Tlish M.M., Gluzmin M.I., Kartashevskaya M.I., Psavok F.A.

Abstract

Goal of the research: to determine the efficacy of a new line of Atopic cosmetic products for skin care in children suffering from atopic dermatitis. Materials and methods: The study involved three groups of 15 children aged 3-12 suffering from atopic dermatitis in each group. Subjects from Group 1 were treated with Atopic Soothing Cream, from Group 2 with Atopic Soothing Stick Cream and from Group 3 with Atopic Everyday Care Cream. Different inclusion and exclusion criteria were developed for each group, and the algorithm for the product application and efficacy criteria were determined. According to recommendations, Atopic Soothing Cream and Atopic Soothing Stick Cream were applied to clean and dry skin in the morning and in the evening for the study period of 14 days. The patients’ skin condition was assessed prior to the study and on Day 14 of the therapy; the assessment covered parameters necessary for calculating the SCORAD Index. Atopic Everyday Care Cream was applied to clean and dry skin in the morning and in the evening for 28 days. The patients’ skin condition was assessed prior to the study and on Days 14 and 28 of the therapy including the SCORAD Index and assessments of the skin hydration level of the epidermal corneous layer and transepidermal waster loss (TEWL) using the DermaLabCombo CORTEX device. According to the study results, the line of Atopic cosmetic products fully complies with the properties specified by the manufacturer, reliably improves the skin condition in children suffering from atopic dermatitis, has no irritant or sensitizing effect, and can be recommended for the complex treatment and rehabilitation of patients suffering from the pathology.
Vestnik dermatologii i venerologii. 2016;92(2):96-102
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Naftifine hydrochloride (NH) in the treatment of pityriasis versicolor
Kotrekhova L.P., Vashkevich A.A., Tsurupa E.N., Reztsova P.A.

Abstract

Introduction & objectives: The purpose of this study was to demonstrate the efficacy comparability of 1% NH lotion vs. of 1% NH cream (exoderil, Sandoz) in the treatment of pityriasis versicolor. Material & methods. 71 patients with pityriasis versicolor were randomly allocated either to receive NH lotion once daily (NH lotion group (п = 35, 38.6 years (95% CI [33,7, 43.5]) or NH cream once daily (NH cream group (п = 36, 40.8 years (95% CI [36,6, 45.0]) for 14 days. Mycological evaluations (microscopy and culture) were performed at weeks 2 and 3, inflammation symptoms evaluations were scored at day 3, weeks 2 and 3 after start of the therapy. Overall cure rates assessment included results of mycological, clinical outcomes and safety evaluation. Results. There was no difference between groups in mycological cure rates (94% vs 92%) and inflammation regression (97% vs 97%). Overall cure rate was 91% and 92% of patients in NH lotion and NH cream groups respectively (p = 0,97). Conclusion. 1% NH lotion and 1% NH cream are effective in the treatment of pityriasis versicolor.
Vestnik dermatologii i venerologii. 2016;92(2):103-109
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PH OF THE TOPICAL DRUG VEHICLE: SELECTING AN OPTIMUM VALUE AND ROLE OF THE BUFFER SYSTEM
Dukhanin A.S.

Abstract

The following three groups of factors must be taken into consideration for selecting an optimum pH value of a topical drug: pharmaceutical, pharmacological and compatibility factors. To ensure a stable pH value, the drug vehicle comprises different buffer systems: single component and two-component ones. The optimum conditions for selecting and maintaining the vehicle pH were examined by the example of glucocorticosteroid-based topical drugs.
Vestnik dermatologii i venerologii. 2016;92(2):110-114
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Topical antibiotics for acne treatment
Silina L.V., Pismennaya E.V., Kolbina M.S.

Abstract

Urgency. Acne is a prevalent polymorphous multifactorial inflammatory disease with various clinical forms ranging from the mildest ones (comedonal) to the most severe forms such as phlegmonous, indurative and cystic acne. According to epidemiology studies, the acne incidence rate in general population varies from 85% to 93%; moreover, there is a trend towards the growth in the incidence rate of postpubertal and persistent acne in adults. Acne treatment methods depend on the adequate clinical assessment of the disease severity, character of eruptions, skin type, any concomitant pathologies and patient’s age. Topical therapy is administered to all patients regardless of the disease severity and forms a mandatory part of the therapeutic complex treatment of acne patients. Despite the range of available drugs and treatment methods, researchers keep searching for new drugs and treatment methods for treating acne. Combination acne therapies enjoy keen interest in the world for reasons such as stable treatment results and improved compliance. It is essential that the administration of a combination therapy came along with drugs having a complimentary mechanism of action. Drug combinations have an effect on a large number of pathogenetic factors resulting in acne (excessive follicular hyperkeratosis, propagation of P. аспвв, inflammation). Goal. The goal of this article is a review of literature sources on current aspects of acne topical therapy and examining results of studies of a combination therapy, azelaic acid and clindamycin. Study materials and methods. The project was carried out at the GBOU VPO Kursk State Medical University, Ministry of Health of the Russian Federation. Major results. Both Russian and foreign authors use combination therapies with topical administration of azelaic acid and clindamycin on a broad scale. According to a study conducted in Russia, azelaic acid is a good combination substance for administration with both topical antibiotics (the antibiotic is to be applied to pustules once a day) and adapalene. According to the clinical study results, 15% azelaic acid (Azelic gel) as a part of a combination topical therapy reduces adverse effects observed in the course of a monotherapy with topical retinoids and improves the therapeutic efficacy when combined with antibacterial drugs. Conclusion. The practical experience and different variants of a combination therapy with 15% azelaic acid (Azelic gel) and 1% clindamycin gel (Clindovit) provide dermatologists with an opportunity to treat acne in different groups of patients on an everyday basis with increased efficacy achieving a longer remission of the inflammatory process.
Vestnik dermatologii i venerologii. 2016;92(2):115-120
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Pleomorphic rhabdomyosarcoma: a case study
Kozlova A.V., Kazakov V.M., Kokh L.N., Ruksha T.G.

Abstract

Pleomorphic rhabdomyosarcoma of the skin is a fast progressing tumor with high risk of development of lymphogenous and hematogenous metastasis, low survival rates and complex diagnostics. this clinical case describes the application of typing tumor cells on the basis of immunohistochemistry to establish the nature of the tumor clone neoplasms.
Vestnik dermatologii i venerologii. 2016;92(2):71-75
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Nodular mastocytosis: a case study
Pavlova E.V., Ulitina I.V., Rusak Y.E., Efanova E.N., Ivannikova E.N.

Abstract

A case study of nodular mastocytosis is described. Tacrolimus was used to treat skin manifestations of mastocytosis.
Vestnik dermatologii i venerologii. 2016;92(2):76-80
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Skin microbiota in patients with psoriasis vulgaris and pustular psoriasis
Bakhlykova E.A., Filimonkova N.N., Timokhina T.K., Kurlovich N.A.

Abstract

In the dermatological community there is no consensus regarding the role of infectious factors in the origin, course, exacerbation of psoriasis. the authors conducted a study on frequency of detection, quantitative and qualitative composition of the microbiota of the skin, mucous membranes of the throat and nose of patients with various forms of psoriasis, the relationship with the clinical picture. The goal of the study was to examine of the composition of the microbiota of the skin, the mucous membranes of the throat and nose of patients with various forms of psoriasis compared with healthy individuals. Materials and methods: inducted bacteriological examination of the surface of psoriatic elements, the contents of the pustules, the mucous membranes of the throat and nose in 49 patients, of them with generalized pustular psoriasis, palmoplantar pustular psoriasis, common exudative psoriasis, and vulgar psoriasis, mainly affecting the palms and soles. Was to study the intensity of the sensation of itching in patients on a 10 - points scale. Results: bacteriological examination of pathological lesions on the skin in patients with various forms of psoriasis highlighted various microorganisms in the diagnostically relevant concentrations with a predominance of gold and epidermal staphylococci. Shows the functional, statistically significant relations hip between the degree of intensity of itching and frequency of detection of Staphylococcus aureus. Conclusion: detection of diagnostically significant quantities of conditionally pathogenic microorganisms with a predominance of gold and epidermal staphylococci shows the possible role of infection in the development of immune inflammation in psoriasis. this regularity of the intensity of itching and detection of Staphylococcus aureus on the surface of the skin of patients with psoriasis may be an important factor in the current understanding of the significance of the role of infection in the development and course of psoriasis.
Vestnik dermatologii i venerologii. 2016;92(2):47-54
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Ultratone therapy for the complex treatment of localized scleroderma
Sorokina N.V., Tlish M.M.

Abstract

The examination and treatment of 48 patients with circumscribed scleroderma were conducted. Two groups of these patients were formed with method of adaptive randomization. In the control group complex treatment underwent according to the standards in this nosology. In the study one, we conducted ultratonotherapy. The course of treatment was 21 days in both groups. Treatment results were evaluated in accordance with the dynamics of cutaneous pathological process and microcirculation in the area of lesions. In the process of treatment positive clinical dynamics appeared in the study group earlier and were accompanied by increased blood flow. The results indicate that ultrasonotherapy increases the efficiency and reduces the treatment time of patients with circuscrimbed scleroderma.
Vestnik dermatologii i venerologii. 2016;92(2):55-58
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Features of clinic and tool diagnostics of infectious (microbic) eczema
Lysenko O.V., Ziganshin O.R., Lukyanchikova L.V.

Abstract

One of frequent forms of eczema is infectious (microbic) eczema, in recent years tending to heavier current. In certain cases differentiation between the endogenous eczema complicated by a piodermiya, and infectious eczema is difficult. The method of the stratified randomization chose 139 patients with infectious eczema and the 50 with endogenous eczema. Manifestations of a disease were compared clinically and by means of a dermatoskopia. At patients with infectious eczema reliable more often the itch had easy temper, only at this group there were a burning and morbidity. the centers of defeat weren’t symmetric and had a clear boundary. Dermatoskopic differences of infectious eczema were a clear boundary, brighter uneven coloring of the center, yellow inclusions, a mesh vascular network (red lines). Two clinical examples are given.
Vestnik dermatologii i venerologii. 2016;92(2):59-64
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Atopic dermatitis in children. A current algorithm for the disease treatment and control
Proshutinskaya D.V.

Abstract

The article discusses key aspects of the pathogenesis of atopic dermatitis and issues of the selection of pathogenetically substantiated therapy methods. The authors provide data on the efficient use of basic drugs used to treat dermatosis in children - topical glucocorticosteroids and calcineurin inhibitors. The authors also describe a current algorithm for using topical calcineurin inhibitors during the period of an exacerbation of atopic dermatitis and to prevent relapses.
Vestnik dermatologii i venerologii. 2016;92(2):65-70
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Prospects of the practical use of nanoparticles in dermatology
Kubanova A.A., Utz S.R., Kubanov A.A., Persati M.A., Svenskaya Y.I.

Abstract

The review presents data from foreign literature sources on the problem of using nanoparticles for theranostics of skin diseases. The article examines properties and operating principles of nanomaterials used most frequently for drug encapsulation and emphasizes advantages of such systems for the treatment of different dermatoses. The need in further exploration of this subject due to underinvestigated adverse events caused by nanoparticles is discussed.
Vestnik dermatologii i venerologii. 2016;92(2):15-20
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Cutaneous rosacea: a thorough overview of pathogenesis, clinical presentations, and current recommendations on management
Del Rosso J.Q.

Abstract

В обзоре обобщены и систематизированы имеющиеся международные данные по патогенезу, клиническим проявлениям и текущим рекомендациям по тактике ведения пациентов с розацеа.
Vestnik dermatologii i venerologii. 2016;92(2):21-31
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Cutaneous rosacea: a thorough overview of pathogenesis, clinical presentations, and current recommendations on management
Del Rosso J.Q.

Abstract

The review summarizes and systemizes available international data on the pathogenesis, clinical manifestations and current recommendations for the management of rosacea patients.
Vestnik dermatologii i venerologii. 2016;92(2):32-40
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Up-to-date laboratory methods for assessing the safety of perfumery and cosmetic products in the quality assurance system of the Russian Federation
Rezaykina A.V., Petrova N.P., Rotanov S.V.

Abstract

Most of the developed countries as well as Russian Federation have a dynamically developing quality assurance system for testing the quality of laboratory tests and safety of perfumery and cosmetic products entering the market comprising a regulatory and legal framework, physical infrastructure and appropriate methodical basis and staff. At the same time, it is necessary to develop alternative test methods adjusted to perfumery and cosmetic products on a regular basis. In addition, it is necessary to optimize methods for ensuring standard sample preparation conditions in response to new forms of cosmetic products when determining microbiological, physical, chemical and toxicological characteristics, and more accurate observation methods for clinical and laboratory indices to be approved by supervising authorities.
Vestnik dermatologii i venerologii. 2016;92(2):41-46
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