Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov113910.25208/vdv1139Research ArticleHoffman's Recalcitrant Dissecting Folliculitis — State of the Problem, Approach to Therapy, Demonstration of Clinical CasesDrozhdinaMarianna B.<p>Professor, PhD, MD, Professor of the department od dermatovenereology and cosmetology</p>drozhdina@yandex.ruhttps://orcid.org/0000-0002-7689-8350BobroVarvara A.<p>Dermatovenerologist</p>bobro.va@inbox.ruhttps://orcid.org/0000-0003-2306-1423FBSEI HE Kirov State Medical University of the Ministry of Health of Russian FederationKirov Regional State Budgetary Healthcare Institution Kirov Regional Clinical Dermatovenereologic Hospital
Semashko0208202096235432205202003062020Copyright © 2020, Drozhdina M.B., Bobro V.A.2020<p style="text-align: justify;">A review of the literature on the etiology, pathogenesis, and evidence base of therapeutic approaches for the management of patients with Hoffman's recalcitrant dissecting folliculitis is presented. The article describes the clinic of the disease, complications and optimal therapeutic tactics at the present stage. Attention is focused on the problem of antibiotic resistance and ways to solve it. A clinical case with a successful therapeutic outcome is presented. The article is illustrated with photos on the patients from the author's archive.</p>Hoffman's recalcitrant dissecting folliculitisfollicular occlusal triadCutibacterium acnesalopeciaantibiotic resistancesystemic isotretinoinподрывающий фолликулит Гоффманафолликулярная окклюзионная триадаCutibacterium acnesалопецияантибиотикорезистентностьсистемный изотретиноин[Luderschmidt C., Klövekorn W. Systemic inflammatory reactions and extracutaneous manifestations of Acne vulgaris. Z Hautkr. 1986; May 1; 61 (9): 617—21.][Kircik L.H. Advances in the Understanding of the Pathogenesis of Inflammatory Acne. J Drugs Dermatol. 2016 Jan 1.15 (1): 7—10.][Tchernev G. Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: systemic antibiosis (metronidazole plus clindamycin), dermatosurgical approach, and high-dose isotretinoin. Indian J Dermatol. 2011 May; 56 (3): 318—20. doi: http://dx.doi.org/10.4103/0019-5154.82492.][Рябова В.В., Кошкин С.В., Зайцева Г.А., Евсеева А.Л. Характер распределения антигенов HLA I класса у пациентов со среднетяжелыми и тяжелыми формами акне. Иммунопатология, аллергология, инфектология. 2017; 3: 75—78. [V.V. Ryabova, S.V. Koshkin, G.А. Zaitseva, A.L. Evseeva. Character of distribution of immunological indicators in patients with average and severe forms of acne. Immunopathology, allergology, infectology. 2017; 3: 75—78 (Russia).] doi: https://doi.org/10.14427/jipai.2017.3.75.][Georgala S., Korfitis C., Ioannidou D., Alestas T., Kylafis G., Georgala C. Dissecting cellulitis of the scalp treated with rifampicin and isotretinoin: case reports. Cutis. 2008 Sep. 82 (3): 195—8.][Bolz S., Jappe U., Hartschuh W. Successful treatment of perifolliculitis capitis abscedens et suffodiens with combined isotretinoin and dapsone. J Dtsch Dermatol Ges. 2008 Jan. 6 (1): 44—7. doi: http://dx.doi.org/10.1111/j.1610-0387.2007.06399.x.][Greenblatt D.T., Sheth N., Teixeira F. Dissecting cellulitis of the scalp responding to oral quinolones. Clin Exp Dermatol. 2007 Nov. 33 (1): 99—100. doi: https://doi.org/10.1111/j.1365-2230.2007.02598.x.][Дрождина М.Б. Применение Акнекутана для лечения фульминантных акне. Консилиум. Дерматовенерология. 2019; 2 (171): 25. [Drozdina M.B. The usage of Aknekutan for the treatment of fulminant acne. Consultation. Dermatovenerology. 2019; 2 (171): 25 (Russia).]][Bowe W.P. Antibiotic resistance and acne: where we stand and what the future holds. J Drugs Dermatol. 2014; 13 (6): 66—70.][Rosen T. Antibiotic resistance: an editorial review with recommendations. J Drugs Dermatol. 2011; 10 (7): 724—33.][Kobayashi H., Aiba S., Tagami H. Successful treatment of dissecting cellulitis and acne conglobata with oral zinc. Br J Dermatol. 1999 Dec. 141 (6): 1137—8. doi: 10.1046/j.1365-2133.1999.03223.x.][Navarini A.A., Trüeb R.M. 3 cases of dissecting cellulitis of the scalp treated with adalimumab: control of inflammation within residual structural disease. Arch Dermatol. 2010 May. 146 (5): 517—20. doi: https://doi.org/10.1001/archdermatol.2010.16.][Wollina U., Gemmeke A., Koch A. Dissecting Cellulitis of the Scalp Responding to Intravenous Tumor Necrosis Factor-alpha Antagonist. J Clin Aesthet Dermatol. Apr. 2016. 174 (4): 916—18. doi: https://doi.org/10.1111/bjd.14269.][Mansouri Y., Martin-Clavijo A., Newsome P., Kaur M.R. Dissecting cellulitis of the scalp treated with tumour necrosis factor-α inhibitors: experience with two agents. Br J Dermatol. Apr. 2016. 174 (4): 916—18. doi: https://doi.org/10.1111/bjd.14269.][Krasner B.D., Hamzavi F.H., Murakawa G.J., Hamzavi I.H. Dissecting cellulitis treated with the long-pulsed Nd:YAG laser. Dermatol Surg. 2006 Aug. 32 (8): 1039—44. doi: https://doi.org/10.1111/j.1524-4725.2006.32227.x.][Boyd A.S., Binhlam J.Q. Use of an 800-nm pulsed-diode laser in the treatment of recalcitrant dissecting cellulitis of the scalp. Arch Dermatol. 2002 Oct. 138 (10): 1291—3. doi: https://doi.org/10.1001/archderm.138.10.1291.][Bellew S.G., Nemerofsky R., Schwartz R.A., Granick M.S. Successful treatment of recalcitrant dissecting cellulitis of the scalp with complete scalp excision and split-thickness skin graft. Dermatol Surg. 2003 Oct. 29 (10): 1068—70. doi: https://doi.org/10.1046/j.1524-4725.2003.29305.x.][Hintze J.M., Howard B.E., Donald C.B., Hayden R.E. Surgical Management and Reconstruction of Hoffman's Disease (Dissecting Cellulitis of the Scalp). Case Rep Surg. 2016. 2016:2123037. doi: https://doi.org/10.1155/2016/2123037.][Liu Y., Ma Y., Xiang L.H. Successful treatment of recalcitrant dissecting cellulitis of the scalp with ALA-PDT: case report and literature review. Photodiagnosis Photodyn Ther. 2013 Dec. 10 (4): 410—3. doi: https://doi.org/10.1016/j.pdpdt.2013.03.008.][Дрождина М.Б. Болезнь Морбигана. Современный обзор литературы. Описание редкого клинического случая. Медицинский вестник Северного Кавказа. 2020; 15 (1): 15—21. [Drozhdina MB. Morbihan disease. A modern review of the literature. Description of a rare clinical case. Medical news of North Caucasus. 2020; 15 (1): 129—133 (Russia).]][Karpouzis A., Giatromanolaki A., Sivridis E., Kouskoukis C. Perifolliculitis capitis abscedens et suffodiens successfully controlled with topical isotretinoin. Eur J Dermatol. 2003 Mar-Apr. 13 (2): 192—5. doi: https://doi.org/10.1001/archdermatol.2010.16.][Jacobs F., Metzler G., Kubiak J. et al. New approach in combined therapy of perifolliculitis capitis abscedens et suffodiens. Acta Derm Venereol. Oct 2011. 91 (6): 726—7. doi: https://doi.org/10.2340/00015555-1146.][Дрождина М.Б. Фульминантные акне. Современное решение проблемы. Вестник дерматологии и венерологии. 2019; 95 (4): 79—86. [Drozhdina M.B. Fulminant acne. Modern solution to the problem. Bulletin of Dermatology and Venereology. 2019; 95 (4): 79—86 (Russia).] doi: https://doi.org/10.25208/0042-4609-2019-95-4-79-86.][Andrea L. Zaenglein, Arun L. Pathy, Bethanee J. Schlosser et al. Guidelines of care for the management of acne vulgaris. JAAD. May 2016. Volume 74, Issue 5, Pages 945–973.e33. doi: https://doi.org/10.1016/j.jaad.2015.12.037.][Arowojolu A.O., Gallo M.F., Lopez L.M., and Grimes D.A. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev. 2012; CD004425/ doi: https://doi.org/10.1002/14651858.cd004425.pub5.][Howard R., Smith G. The readability of iPledge program patient education materials. J. Am. Acad. Dermatol. 2018. doi: http://dx.doi.org/10.1016/j.jaad.2018.05.038.]