Dynamics of the sensitivity of N. gonorrhoeae strains found in the territory of the Russian Federation in 2010-2013 to antimicrobial drugs used for the treatment of gonococcal infection

Cover Page

Abstract


Goal of the study. To study the sensitivity of N. gonorrhoeae strains found in the territory of the Russian Federation in 2010- 2013 to antimicrobial drugs. Materials and methods. During the monitoring of antibiotic resistance of N. gonorrhoeae in 2010-2013, phenotypic properties of N. gonorrhoeae strains to antimicrobial drugs (penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin and ceftriaxone) were examined by the agar serial dilution technique. As many as 1,305 viable N. gonorrhoeae strains from different regions of the russian Federation were examined. The results were evaluated according to the criteria such as CLSI (Clinical and Laboratory Standards Institution) and EUCAST (European Committee for Antimicrobial Susceptibility Testing). The results were processed by using the WHONET software, version 5.4. Results. According to the results of a study of N. gonorrhoeae antibiotic resistance, N. gonorrhoeae is highly resistant to penicillin (in 2010 - 72.4%, in 2011 - 50.6%, in 2012 - 51.2%, in 2013 - 49.3%), to tetracycline (in 2010 - 68.5%, in 2011 - 55%, in 2012 - 61.9%, in 2013 - 49.3%) and ciprofloxacin (in 2010 - 56.2%, in 2011 - 37.1%, in 2012 - 35%, in 2013 - 24.6%) for the entire observation period without any substantial trend towards its reduction. During studies of the resistance of the gonococcal infection pathogen to spectinomycin, the share of non-sensitive strains to the antibiotic reduced from 16.7% in 2010 to 0.7% in 2013. A slight reduction in the share of non-sensitive N. gonorrhoeae strains to azithromycin was also observed (in 2010 - 15.3%, in 2011 - 25.3%, in 2012 - 17.5%, in 2013 - 9.9%) yet these data substantially exceed the level recommended by the WHO for prescribing an antimicrobial therapy. A high level of N. gonorrhoeae sensitivity to ceftriaxone (100%) was revealed in 2010-2013. Conclusions. According to the analysis of resistance of N. gonorrhoeae strains to antimicrobial drugs found in the territory of the russian Federation in 2010-2013, there is a trend towards the reduction in the number of non-sensitive N. gonorrhoeae strains to penicillin, tetracycline, ciprofloxacin, spectinomycin and azithromycin, which can confirm the efficacy of the Neisseria gonorrhoeae antibiotic resistance monitoring measures taken by State research Center of Dermatovenereology and Cosmetology since 2002.

V. S. Solomka

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: solomka@cnikvi.ru

Russian Federation

  1. Ресурсы и деятельность медицинских организаций дерматовенерологического профиля. Заболеваемость инфекциями, передаваемыми половым путем, заразными кожными болезнями и болезнями кожи (Статистические материалы) М, 2014; 236
  2. Surveillance Report. www.ecdc.europa.eu. Annual epidemiological report Reporting on 2011 surveillance data and 2012 epidemic intelligence data, 2013 http://www.ecdc.europa.eu/en/pub-lications/publications/annual-epidemiological-report-2013.pdf
  3. Lee K., Chong Y., Erdenechemeg L., et al. Incidence, epidemiology and evolution of reduced susceptibility to ciprofloxacin in Neisseria gonorrhoeae in Korea. Clinical microbiology and infection 1998; 4 (11): 627-633.
  4. Ye S., Su X., Wang Q. et al. Surveillance of antibiotic resistance of Neisseria gonorrhoeae isolates in China, 1993-1998. Sexually transmitted diseases 2002; 29 (4): 242-245.
  5. Arreasa L., Salsedo C., Alcala B. et al. Antibiotic resistance of Neisseria gonorrhoeae in Spain: trends over the last two decades. The Journal of antimicrobial chemotherapy 2003; 51 (1): 153-156.
  6. Nissinen A., Jarvinen H., Liimatainen O. et al. Antimicrobial resistancein Neisseria gonorrhoeae in Finland, 1976 to 1995. Sexually transmitted diseases 1997; 24 (10): 576-581.
  7. Dan M., Poch F., Shneinberg B. High prevalence of high-level ciprofloxacin resistance in Neisseria gonorrhoeae in Tel Aviv, Israel: correlation with response to therapy. Antimicrobial agents and chemotherapy 2002; 46 (6): 1671-1673.
  8. Wang S.A., Harvey A.B., Conner S.M. et al. Antimicrobial Resistance for Neisseria gonorrhoeae in the United States, 1988 to 2003: The Spread of Fluoroquinolone Resistance. Annals of internal medicine 2007; 147 (2): 81-88.
  9. Tapsall J.W., Limnios E.A., Murphy D. Analysis of trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Australia, 1997-2006. The Journal of antimicrobial chemotherapy 2008; 61 (1): 150-155.
  10. Lina B.L., Pastorea R., Liassinec N. et al. A new sexually transmitted infection (STI) in Geneva? Ciproloxacin-resistant Neisseria gonorrhoeae, 2002-2005. Swiss medical weekly 2008; 138 (15-16): 243-246.
  11. Chisholm S.A., Neal T.J., Alawattegama A.B. et al. Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales. The Journal of antimicrobial chemotherapy 2009; 64 (2): 353-358.
  12. Whiley D.M., Limnios E.A., Ray S. et al. Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. Antimicrobial agents and chemotherapy 2007; 51 (9): 3111-3116.
  13. Tapsall J.W. Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins. Current opinion in infectious diseases 2009; 22 (1): 87-91.
  14. Monfort L., Caro V., Devaux Z. et al. First Neisseria gonorrhoeae genotyping analysis in France: identification of a strain cluster with reduced susceptibility to ceftriaxone. Journal of clinical microbiology 2009; 47 (11): 3540-3545.
  15. Кубанова А.А., Сидоренко С.В., Фриго Н.В. и др. Новые биомедицинские технологии в контроле над распространением инфекций, передаваемых половым путем, на территории Российской Федерации. Вестн дерматол венерол 2008; (2): 4-14
  16. Kubanova A., Frigo N., Kubanov A. et al. The Russian gonococcal antimicrobial susceptibility programme (RU-GASP) - national resistance prevalence in 2007 and 2008, and trends during 2005-2008. Eurosurveillance 2010; 15 (14): 10-14.
  17. Стандартные операционные процедуры по забору клинического материала у пациентов с подозрением на гонококковую инфекцию (СОП № ГОН 002/04). М: ДЭКС-ПРЕСС; 2008
  18. Кубанова А.А., Фриго Н.В., Кубанов А.А. и др. Стандартные операционные процедуры по транспортировке и доставке клинического материала и выделенных культур возбудителя гонореи (СОП № ГОН 001/03). М: ДЭКС-ПРЕСС; 2008
  19. Кубанова А.А., Кубанов А.А., Фриго Н.В. и др. Стандартные операционные процедуры по проведению видовой идентификации возбудителя гонореи. Сборник стандартных операционных процедур (СОП № ГОН 003/04; СОП № ГОН 004/04; СОП № ГОН 005/04). М: ДЭКС-ПРЕСС; 2008
  20. Определение чувствительности микроорганизмов к антибактериальным препаратам (Методические указания МУК 4.2.1890-04). Клиническая микробиология и антимикробная химиотерапия 2004; 6 (4): 306-356
  21. Кубанова А.А., Фриго Н.В., Кубанов А.А. и др. Стандартные операционные процедуры по методам определения чувствительности гонококка к антибактериальным препаратам (СОП № ГОН 006/03). М: ДЭКС-ПРЕСС; 2008
  22. Clinical and Laboratory Standards Institute: Performance standards for antimicrobial susceptibility testing, 24th informational supplement, CLSI document M100-S24. Wayne, PA: CLSI; 2014
  23. Страчунский Л.С., Сехин С.В., Борисенко К.К. и др. Чувствительность гонококков к антибиотикам и выбор препаратов при гонококковой инфекции. Инфекции, передаваемые половым путем, 1999; (2): 26-29
  24. Лесная И.Н., Соломка В.С., Фриго Н.В. и др. Выбор препаратов для лечения гонококковой инфекции на основании результатов мониторинга антибиотикорезистентности N. gonorrhoeae. Вестн дерматол венерол 2010; (5): 65-73
  25. Antimicrobial resistance in gonococci, WHO Western Pacific Region, 1996. The WHO Western Pacific Region Gonococcal Antimicrobial Surveillance Programme. Communicable diseases intelligence 1997; 21(23): 349-353
  26. Кубанова А.А., Сехин С.В., Якушин С.Б., Кубанов А.А. Антибактериальная терапия гонореи в свете последних международных рекомендаций. Клин микробиол антимикр химиотер 2002; 4 (4): 364-378

Views

Abstract - 48

PDF (Russian) - 13

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies