Experience use of azelaic acid in patients with acne

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Abstract


Treatment of acne is one of the important problems of modern dermatology. The goal of the research. The study of clinical efficacy and safety of the 15% azelaic acid in the form of Azelik-gel in the treatment of patients with papulo-pustular acne, mild to moderate in severity. Material and methods. Open comparative study of 8 weeks, which was attended by 75 patients. To assess the safety and efficacy of the therapy was performed clinical and biochemical blood and urine tests, evaluation of dermatological status, measurement of pH, moisture and oiliness of skin and analysis of DLQI. Results. 82% of patients receiving the Azelik-gel, marked clinical improvement or significant improvement. Conclusions. The results of the study indicate a high level of safety and tolerability of the Azelik-gel and obtained clinical results have shown its therapeutic efficacy in the treatment of papulo-pustular acne mild to moderate in severity.

A. V. Statsenco

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Author for correspondence.
Email: statsenco-a@mail.ru

Russian Federation

U. G. Gorbunov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

V. R. Khairutdinov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

N. E. Shestopalov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

O. V. Antonova

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

  1. Dawson A., Dellavalle R. Acne vulgaris. BMJ 2013; 8: 346.
  2. Knutsen-Larson S., Dawson A.L., Dunnick C.A., Dellavalle R.P. Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatol Clin 2012; 30: 99-106.
  3. Nast A., Dreno B., Bettoli V. et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26 (1): 1-29.
  4. Thiboutot D., Gollnick H., Bettoli V. et al. New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group. J Am Acad Dermatol, 2009; 60: S1-50.
  5. Gollnick H.P., Graupe K., Zaumseil R.P. Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies. J Dtsch Dermatol Ges, 2004; 2: 841-847.
  6. Bojar R.A., Cunliffe W.J., Holland K.T. Disruption of the transmembrane pH gradient - a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. J Antimicrob Chemother. 1994; 34: 3: 321-30.
  7. Kakita L.S., Lowe N.J. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. Clin Ther. 1998; 20 (5): 960-70.
  8. Mastrofrancesco A., Ottaviani M., Aspite N. et al. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol. 2010; 19 (9): 813-20.
  9. Dukhanin A.S. Modern criteria of rational pharmacotherapy of acne at women. Point of view of the clinical pharmacologist. Westnik dermatologii I venerologii. 2012; 2: 108-17. [Духанин А.С. Современные критерии рациональной фармакотерапии акне у женщин. Взгляд клинического фармаколога. Клин. дерматол. и венерол. 2012; 2: 108-17.]

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