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Фотостарение кожи: механизмы развития, особенности клинических проявлений

https://doi.org/10.25208/0042-4609-2014-0-5-53-59

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Аннотация

В статье представлены современные литературные данные, касающиеся механизмов развития фотостарения кожи, вызванного ультрафиолетовым излучением УФА- и УФБ-спектров. Результатом длительного воздействия УФ-излучения являются повреждение геномной ДНК, развитие мутаций ДНК, повреждение белков, мембранных липидов, коллагеновых и эластических волокон, деградация межклеточного вещества дермы, развитие хронического воспаления, иммуносупрессия, нарушение меланогенеза и усиление ангиогенеза. Описаны основные клинические проявления фотостарения, проявляющиеся на коже, и представлена их гистологическая характеристика.

Об авторах

А. А. Кубанов
ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России
Россия


М. Б. Жилова
ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России
Россия


А. А. Кубанова
ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России
Россия


Список литературы

1. Zins J.E., Moreira-Gonzalez A. Cosmetic procedures for the ageing face. Clin Geriatr Med 2006; 22: 709-28.

2. Webster G.F. Common skin disorders in the elderly. Clin Cornerstone 2001; 4: 39-44.

3. Bosset S., Barré P., Chalon A., Kurfurst R., Bonté F., André P., Perrier P., Disant F., Le Varlet B., Nicolas J.F. Skin ageing: clinical and histopathological study of permanent and reducible wrinkles. Eur J Dermatol 2002; 12: 247-52.

4. Krutmann J., Gilchrest B.A. Photoaging of skin. In: Skin Aging (Gilchrest B.A., Krutmann J., eds), Berlin: Springer-Verlag, 2006; 33-43.

5. Rabe J.H., Mamelak A.J., Mc Elgunn P.J., Morison W.L., Sauder D.N. Photoageing: mechanisms and repair. J Am Acad Dermatol 2006; 55: 1-19.

6. Just M., Ribera M., Monso E., Lorenzo J.C., Ferrandiz C. Effect of smoking on skin elastic fibres: morphometric and immunohistochemical analysis. Br J Dermatol 2007; 156: 85-91.

7. Tsukahara K., Moriwaki S., Hotta M., Fujimura T., Kitahara T. A study of diurnal variation in wrinkles on the human face. Arch Dermatol Res 2004; 296: 169-74.

8. Stege H., Roza L., Vink A., Grewe M., Ruzicka T., Grether-Beck S. and Krutmann J. Enzyme plus light therapy to repair immunosuppressive effects on human skin damaged by ultraviolet B-radiation. Proc Natl Acad Sci USA 2000; 97: 179-5.

9. Ravanat J.L. et all. Direct and indirect effects of UV radiation on DNA and its components. J. Photochem. Photobiol. B 2001, 63, 88-102.

10. Courdavault S. et all. Repair of the three main types of bipyrimidine DNA photoproducts in human keratinocytes exposed to UVB and UVA radiations. DNA Repair 2005; 4: 836-844.

11. Voll R.E., Herrmann M., Roth E.A., Stach C., Kalden J.R., Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature 1997; 390, 350-351.

12. Sander C.S., Chang H., Salzman S., Müller C., Ekanayake-Mudiyanselage S., Elsne P., Thiele J. Photoaging is Associated with Protein Oxidation in Human Skin In Vivo Journal of Investigative Dermatology 2002; 118, 618-625.

13. Bulteau A.L., Moreau M., Nizard C. et al. Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes.Free Radic Biol Med 2002; 32: 1157-70.

14. Levine R.L., Stadtman E.R. Oxidative modification of proteins during aging. Exp Gerontol. 2001 Sep; 36 (9): 1495-502.

15. Yano K., Kadoya K., Kajiya K. et al. Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by down-regulation of thrombospondin-1. Br J Dermatol 2005; 152: 115-21.

16. Howell B.G., Wang B., Freed I. et al. Microarray analysis of UVB regulated genes in keratinocytes: downregulation of angiogenesis inhibitor t hrombospondin-1. J Dermatol Sci 2004; 34: 185-94.

17. Berneburg M., Plettenberg H., Krutmann J. Photoaging of human skin. Photodermatology, Photoimmunology & Photomedicine 2000; 16: 239-44.

18. Oh J.H., Kim A., Park J.M. et al. Ultraviolet B-induced matrix metalloproteinase- and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts. J Cell Physiol 2006; 209: 775-85.

19. Ballard J.W., Dean M.D. The mitochondrial genome: mutation, selection and recombination. Curr Opin Genet Dev 2001; 11: 667-72.

20. Sudel K.M., Venzke K., Knussmann-Hartig E. et al. Tight control of matrix metalloproteinase-1 activity in human skin. Photochem Photobiol 2003; 78: 355-60.

21. Berneburg M., Grether-Beck S., Kurten V., Ruzicka T., Briviba K., Sies H., Krutmann J. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem 1999; 274: 15 345-9.

22. Berneburg M., Gattermann N., Stege H., Grewe M., Vogelsang K., Ruzicka T., Krutmann J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem Photobiol 1997; 66: 271-5.

23. Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992; 256: 628-32.

24. Cortopassi G.A., Shibata D., Soong N.W. et al. A pattern of accumulationof a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992; 89: 7370-4.

25. Cortopassi G.A., Shibata D., Soong N.W. et al. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992; 89: 7370-4.

26. DiMauro S., Schon E.A. Mitochondrial respiratory-chain diseases. N Engl J Med 2003; 348: 2656-68.

27. Birch-Machin M.A., Tindall M., Turner R. et al. Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging. J Invest Dermatol 1998; 110: 149-52.

28. Grether-Beck S., Oliazola-Horn S., Schmitt H., Grewe M., Jahncke A., Johnson J.P., Briviba K., Sies H., Krutmann J. Activation of transcription factor AP-2 mediates ultraviolet A radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule-1 gene. Proc Natl Acad Sci USA 1996; 93: 14586-91.

29. Srivastava S., Moraes C.T. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum Mol Genet 2005; 14: 893-902.

30. Yang J.H., Lee H.C., Lin K.J. et al. A specific 4977-bp deletion of mitochondrial DNA in human ageing skin. Arch Dermatol Res 1994; 286: 386-90.

31. Xu Y., Shao Y., Voorhees J.J. et al. Oxidative inhibition of receptortype protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. J Biol Chem 2006; 281: 27 389-97.

32. Fisher G.J., Talwar H.S., Lin J. et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 1998; 101: 1432-40.

33. Fisher G.J., Datta S.C., Talwar H.S. et al. Molecular basis of suninduced premature skin ageing and retinoid antagonism. Nature 1996; 379: 335-9.

34. Garmyn M., Yarosh D.B. The molecular and genetic effects of ultraviolet radiation exposure on skin cells. In: Photodermatology (Lim H.W., Honigsman H., Hawk JLM, eds). New York: Informa Healthcare, 2006; 41-50.

35. Fisher G.J., Kang S., Varani J. et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002; 138: 1462-70.

36. Pittelkow M.R., Coffey R.J. Jr., Moses H.J. Keratinocytes produce and are regulated by transforming growth factors. Ann N Y Acad Sci 1988; 548: 211-24.

37. Heldin C.H., Miyazono K., ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-71.

38. Shi Y., Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700.

39. Dijke P., Hill C.S. New insights into TGF-beta- Smad signalling. Trends Biochem Sci 2004; 29: 265-73.

40. Hayashi H., Abdollah S., Qiu Y. et al. The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997; 89: 1165-73.

41. Quan T., He T., Kang S. et al. Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J Invest Dermatol 2002; 119: 499-506.

42. Quan T., He T., Voorhees J.J. et al. Ultraviolet irradiation blocks cellular responses to transforming growth factor-beta by down-regulating its type-II receptor and inducing Smad7. J Biol Chem 2001; 276: 26349-56.

43. Quan T., He T., Kang S. et al. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol 2004; 165: 741-51.

44. Fisher G.J., Datta S., Wang Z. et al. c-Jundependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. J Clin Invest 2000; 106: 663-70.

45. Quan T., He T., Shao Y. et al. Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol 2006; 169: 482-90.

46. Angel P., Szabowski A., Schorpp-Kistner M. Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 2001; 20: 2413-23.

47. Kang S., Fisher G.J., Voorhees J.J. Photoaging: pathogenesis, prevention and treatment. In: Geriatric Dermatology (Gilchrest BA, ed.). Philadelphia: WB Saunders, 2001; 643.

48. Ruland J., Mak T.W. Transducing signals from antigen receptors to nuclear factor kappa B. Immunol Rev 2003; 193: 93-100.

49. Rijken F., Kiekens R.C., Bruijnzeel P.L. Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin. Br J Dermatol 2005; 152: 321-8.

50. Varani J., Spearman D., Perone P. et al. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol 2001; 158: 931-5.

51. Eller M.S., Hadshiew I.M., Puri N. et al. The single-stranded telomeric DNA induces DNA damage responses. J Invest Dermatol 2000; 114: 756.

52. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. / Proc Natl Acad Sci USA, 1992, v. 89, 10 114-10 118.

53. Olovnikov A.M.(Stember, 1973). A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41 (1): 181-90.

54. Miyamura Y., Coelho S.G., Wolber R., Miller S.A., Wakamatsu K., Zmudzka B.Z., Ito S., Smuda C., Passeron T., Choi W., Batzer J., Yamaguchi Y., Beer J.Z., Hearing V.J. Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res 2007; 20: 2-13.

55. Noblesse E., Nizard C., Cario-André M., Lepreux S., Pain C., Schnebert S., Taïeb A., Kurfurst R. Skin ultrastructure in senile lentigo. Skin Pharmacol Physiol. 2006; 19 (2): 95-100.

56. Вольф К. и др. Дерматология Фицпатрика в клинической практике. Т. 2. М: Бином 2012.

57. Montagna W., Kirchner S., Carlisle K. Histology of sun-damaged human skin. J Am Acad Dermatol 1989; 21: 907-18.

58. Bhawan J., Oh C.H., Lew R. et al. Histopathologic differences in the photoaging process in facial versus arm skin. Am J Dermatopathol 1992; 14: 224-30.

59. Brenner M., Hearing V.J. The protective role of melanin against UV damage in human skin. Photochem Photobiol 2008; 84: 539-549.

60. Seite S., Zucchi H., Septier D., Igondjo-Tchen S., Senni K., Godeau G. Elastin changes during chronological and photo-ageing:The important role of lysozyme. J Eur Acad Dermatol Venereol 2006; 20: 980-7.

61. Warren R., Gartstein V., Kligman A.M., Montagna W., Allendorf R.A., Ridder G.M. Age, sunlight and facial skin: A histologic and quantitative study. J Am Acad Dermatol 1991; 25: 751-60.

62. Fisher G.J., Wang Z.Q., Datta S.C., Varani J., Kang S. & Voorhees J.J. (1997). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337 (20), 1419-1428.

63. Fitzpatrick’s Dermatology in General Medicine (Freedberg I.M., Eisen A.Z., Wolff K., Austen K.F., Goldsmith L.A., Katz S.I., eds), 6th edn. New York: McGraw Hill, 2003; 1386-98.

64. Gilchrest B.A. (1990). Skin aging and photoag-ing.Dermatology Nursing, 2 (2): 79-82.


Для цитирования:


Кубанов А.А., Жилова М.Б., Кубанова А.А. Фотостарение кожи: механизмы развития, особенности клинических проявлений. Вестник дерматологии и венерологии. 2014;(5):53-59. https://doi.org/10.25208/0042-4609-2014-0-5-53-59

For citation:


Kubanov A.A., Zhilova M.B., Kubanova A.A. Skin photoageing: mechanisms of development and particular features of clinical manifestations. Vestnik dermatologii i venerologii. 2014;(5):53-59. (In Russ.) https://doi.org/10.25208/0042-4609-2014-0-5-53-59

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