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Актинический кератоз - обзор литературы

https://doi.org/10.25208/0042-4609-2014-0-5-42-52

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Аннотация

Актиническому кератозу (АК) в основном подвержены пожилые люди со светлой кожей. За последние годы в связи с демографическими изменениями увеличилась распространенность АК. установленным фактором риска, приводящим к возникновению мутаций в антионкогене TP53 и онкогене H-Ras, является хроническое ультрафиолетовое воздействие (работа на открытом воздухе), которое способствует внутриэпидермальной пролиферации атипичных кератиноцитов. термин «поле канцеризации» характеризуется наличием множественного АК в участках, подверженных УФ-облучению. также АК называется преинвазивной плоскоклеточной карциномой или плоскоклеточной карциномой in situ. Риск превращения АК в плоскоклеточную карциному составляет 6-10%. Во избежание инвазивного роста рекомендуется лечение на ранних стадиях. За последние годы были разработаны различные варианты терапевтического лечения. В зависимости от степени выраженности признаков существуют методы терапии, направленные на поврежденные участки и дающие превосходные косметические и клинические результаты.

Об авторах

T. Strunk
Academic Teaching Hospital
Россия


L. Braathen
Dermatology Bern
Россия


R. Szeimies
Academic Teaching Hospital
Россия


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Для цитирования:


., ., . Актинический кератоз - обзор литературы. Вестник дерматологии и венерологии. 2014;(5):42-52. https://doi.org/10.25208/0042-4609-2014-0-5-42-52

For citation:


Strunk T..., Braathen L.R., Szeimies R.-. Actinic keratoses - a systemic review. Vestnik dermatologii i venerologii. 2014;(5):42-52. (In Russ.) https://doi.org/10.25208/0042-4609-2014-0-5-42-52

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