A case of borderline tuberculoid leprosy with atypical and complicated manifestations

Cover Page


Cite item

Full Text

Abstract

This article presents a clinical case of a 52-year-old man suffering from oligobacillary border-tuberculoid leprosy in the acute phase associated with an established diagnosis of pulmonary tuberculosis and hepatitis C.

Aim: to present a clinical case of leprosy with atypical and complicated manifestations.

Materials and methods. A 52-year-old patient had been receiving treatment for allergic dermatitis for a long time.

Results. The patient was diagnosed with: A 30.2. Borderline tuberculoid leprosy (Paucibacillary Leprosy, Borderline tuberculoid form. Acute phase). The patient demonstrated atypical complications of the leprosy process in the form of ulcerative necrotic rashes.

About the authors

V. G. Semenova

State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation

Author for correspondence.
Email: v.g.semenova@mail.ru

Director, Sergiev Posad Branch,

Korolenko str., 3, bldg 6, Moscow, 107076

Russian Federation

A. E. Karamova

State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Cand. Sci. (Med.), Head of the Dermatology Department,

Korolenko str., 3, bldg 6, Moscow, 107076

Russian Federation

M. A. Nefyodova

State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Pathologist, Department of Pathomorphology, Juniour Researcher, Dermatology Department,

Korolenko str., 3, bldg 6, Moscow, 107076

Russian Federation

V. V. Chebotarev

Stavropol State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Dr. Sci. (Med.), Prof., Head of the Department of Dermatovenerology and Cosmetology with a Course of Further Professional Education,

Mira str., 310, Stavropol, 355017

Russian Federation

M. A. Zemtsov

Regional Clinical Dermatovenerologic Dispensary of Stavropol Krai

Email: fake@neicon.ru

Cand. Sci. (Med.), Chief Physician,

Dostoevskogo str., 52, Stavropol, 355020

Russian Federation

A. V. Odinets

Regional Clinical Dermatovenerologic Dispensary of Stavropol Krai

Email: fake@neicon.ru

Cand. Sci. (Med.), Departmental Head, 

Dostoevskogo str., 52, Stavropol, 355020

Russian Federation

E. N. Shikhanova

Regional Clinical Dermatovenerologic Dispensary of Stavropol Krai

Email: fake@neicon.ru

Cand. Sci. (Med.), Departmental Head,

Dostoevskogo str., 52, Stavropol, 355020

Russian Federation

E. S. Chumakova

Regional Clinical Tuberculosis Dispensary of Stavropol Krai

Email: fake@neicon.ru

Cand. Sci. (Med.), Head of the Department for Patients with Tuberculosis of the Respiratory System No. 2,

Dostoevskogo str., 56, Stavropol, 355019

Russian Federation

References

  1. Cogen A. L., Walker S. L., Roberts C. H., Hagge D. A., Neupane K. D., Khadge S. et al. Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions. PLoS Negl Trop Dis. 2012;11:e1869.
  2. Boggild A. K., Keystone J. S., Kain K. C. Leprosy: a primer for Canadian physicians. CMAJ. 2004;170(1):71–78.
  3. Graham A., Furlong S., Margoles L. M., Owusu K., Franco-Paredes C. Clinical management of leprosy reactions. Infect Dis Clin Pract. 2010;18:235–238.
  4. Pattyn S. R. Search for effective short-course regimen for the treatment of leprosy. Int J Lepr.61:76–81.
  5. Walker S. L., Lockwood D. N. J. Leprosy. Clin Dermatol. 2007;25:165–172.
  6. WHO. Weekly epidemiological record. 2018;93:445–456.
  7. Donoghue H. D., Marcsik A., Matheson C., Vernon K., Nuorala E., Molto J. E. et al. Co-infection of mycobacterium tuberculosis and mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy. Proc Biol Sci. 2005;272(1561):389–394.
  8. Rawson T. M., Anjum V., Hodgson J. et al. Leprosy and tuberculosis concomitant infection: a poorly understood, age-old relationship. Lepr Rev. 2014;85:288–295.
  9. Setia M. S., Steinmaus C., Ho C. S., Rutherford G. W. The role of BCG in prevention of leprosy: a meta-analysis. Lancet Infect Dis. 2006;6:162–170.
  10. Hohmann N., Voss-Bohme A. The epidemiological consequences of leprosy-tuberculosis co-infection. Mathematical Biosciences. 2013;241:225–237.
  11. Chaussinand R. Tuberculose et lepre, maladies antagoniques. Int J Lepr. 1948;16:431–438.
  12. Lietman T., Porco T., Blower S. Leprosy and tuberculosis: The epidemiological consequences of cross immunity. Am J Public Health. 1997;87:1923–1927.
  13. Kumar B., Kaur S., Kataria S., Roy S.N. Concomitant occurrence of leprosy and tuberculosis — a clinical, bacteriological and radiological evaluation. Lepr India. 1982;54:671–676.
  14. Lee H. N., Embi C. S., Vigelan K. M., White C. R. Jr. Concomitant pulmonary tuberculosis and leprosy. J Am Acad Dermol. 2003;49:755–757.
  15. Ridley D. S., Jopling W. H. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–273.
  16. Sadhu S., Khaitan B. K., Joshi B., Sengupta U., Nautiyal A. K., Mitra D. K. Reciprocity between regulatory T cells and Th17 cells: relevance to polarized immunity in leprosy. PLoS Negl Trop Dis. 2016;10:e0004338.
  17. Britton W. J., Lockwood D. N. Leprosy. Lancet. 2004;363:1209– 1219.
  18. Eichelmann K., Gonzalez Gonzalez S. E., Salas-Alanis J. C., Ocampo-Candiani J. Leprosy. An update: definition, pathogenesis, classification, diagnosis and treatment. Actas Dermosifiliogr. 2013;104(7):554–563.
  19. Geluk A. Correlates of immune exacerbations in leprosy. Semin Immunol. 2018;39:111–118.
  20. Fonseca A. B., Simon M. D., Cazzaniga R. A. et al. The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy. Infect Dis Poverty. 2017;6:5.
  21. De Montjoye L., Spanoudi-Kitrimi I., Marot L., Ferreira De Castro Moutinho I., De Greef J., Yombi J. C. et al. Leg ulcers as an atypical presentation of Mycobacterium leprae infection. Eur J Dermatol. 2018;28(1):105–106.
  22. Sunandini A., Dhanyasree, Suryanarayana, Subhasini, Padmasree. Type 2 lepra reaction with ulceration (erythema necroticans): a case report. Journal of Evolution of Medical and Dental Sciences. 2015;4(15):2630– 2634.
  23. Machado P. R., Machado L. M., Shibuya M., Rego J., Johnson W. D., Glesby M. J. Viral Coinfection and leprosy outcomes: a cohort study. PloS Negl Trop Dis. 2015;9(8):e0003865.
  24. Satta R., Biondi G. Vasculitis and infectious diseases. G Ital Dermatol Venereol. 2015;150(2):211–220.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Semenova V.G., Karamova A.E., Nefyodova M.A., Chebotarev V.V., Zemtsov M.A., Odinets A.V., Shikhanova E.N., Chumakova E.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies