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Линеарный IgA-зависимый буллезный дерматоз

https://doi.org/10.25208/0042-4609-2018-94-6-42-51

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Аннотация

Цель: представить клинический случай линеарного IgA-зависимого буллезного дерматоза.

Материал и методы. Пациентке в возрасте 44 лет, обратившейся с жалобами на высыпания на коже туловища и конечностей, сопровождавшиеся выраженным зудом, были проведены морфологическое исследование биоптата кожи из очага поражения и исследование биоптата видимо непораженной кожи методом непрямой иммунофлюоресценции.

Результаты. У пациентки с высыпаниями в виде множественных пузырьков и мелких пузырей с плотной покрышкой, которые группировались в фигуры, напоминающие жемчужные ожерелья, обнаружено очаговое формирование субэпидермальных щелей, на одном из участков — субэпидермальный пузырь, а также линейное отложение IgA вдоль базальной мембраны эпидермиса. На основании данных клинической картины, гистологического и иммунофлюоресцентного исследований биоптатов кожи был установлен диагноз линеарного IgA-зависимого дерматоза. Регресс высыпаний достигнут в результате системной терапии преднизолоном в дозе 50 мг в сутки.

Заключение. Для диагностики линеарного IgA-зависимого буллезного дерматоза необходимо проведение исследования биоптата кожи методом непрямой иммунофлюоресценции. Эффективным средством терапии больных этим заболеванием являются системные глюкокортикостероиды.

Об авторах

Л. Ф. Знаменская
Государственный научный центр дерматовенерологии и косметологии Министерства здравоохранения Российской Федерации
Россия

д.м.н., ведущий научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6



В. В. Чикин
Государственный научный центр дерматовенерологии и косметологии Министерства здравоохранения Российской Федерации
Россия

д.м.н., старший научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6



М. А. Нефедова
Государственный научный центр дерматовенерологии и косметологии Министерства здравоохранения Российской Федерации
Россия

младший научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6



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Для цитирования:


Знаменская Л.Ф., Чикин В.В., Нефедова М.А. Линеарный IgA-зависимый буллезный дерматоз. Вестник дерматологии и венерологии. 2018;94(6):42-51. https://doi.org/10.25208/0042-4609-2018-94-6-42-51

For citation:


Znamenskaya L.F., Chikin V.V., Nefedova M.A. Linear IgA bullous dermatosis. Vestnik dermatologii i venerologii. 2018;94(6):42-51. (In Russ.) https://doi.org/10.25208/0042-4609-2018-94-6-42-51

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