Clinical experience of using metronidazole as an external therapy of acne

Cover Page

Abstract


Metrogyl gel for external use (metronidazole 1%) has an antioxidant activity and substantially reduces the production of active oxygen compounds by neutrophilic leukocytes in the skin. A combination therapy of light to moderate acne with the use of external retinoids and metronidazole can be more efficient than a monotherapy with the use of these drugs alone. Goal. To assess the clinical efficacy, safety and tolerability of Metrogyl gel for external use in a combination with Klenzit gel (adapalene 0.1%) for treatment of patients with acne vulgaris. Materials and methods. The authors conducted an open-label controlled study of the efficacy, safety and tolerability of Metrogyl gel for external use in a combination with Klenzit gel for external use. As many as 50 patients suffering from acne vulgaris took part in the study, which lasted for eight weeks. The subjects were subdivided into two groups: combination therapy (Group 1, n = 15) and monotherapy with the use of external retinoids (Group 2, n = 15). Results. Adverse effects such as dry skin and peeling were observed among the patients from Group 1 less often (by 3.3 times - 5/35 (14.3%) of cases) than in Group 2 (7/15 (46.7%) of cases) (p = 0.036). The total share of acne patients with clinical recovery and substantial improvement in Group 1 was 33/35 (94.3%), which is 41.4% as much as in Group 2 (10/15 (66.7%)) (p = 0.033). Conclusions. A combination of Metrogyl gel and external retinoids is more efficient than a monotherapy with the use of topical retinoid alone, and such a therapy demonstrates higher tolerability.

A. V. Statsenko

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Author for correspondence.
Email: statsenko-a@mail.ru

Russian Federation

A. A. Bozhchenko

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

YU. G. Gorbunov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

V. R. Khairutdinov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

  1. Saitta P., Keehan P., Yousif J. et al. An update on the presence of psychiatric comorbidities in acne patients. Part 1: overview of prevalence. Cutis 2011; 88: (1): 33-40.
  2. Smithard A., Glazebrook C., Williams H.C. Acne prevalence, knowledge about acne and psychological morbidity in mid-adolescence: a community-based study. Br J Dermatol 2001; 145: (2): 274-279.
  3. Well D. Acne vulgaris: A review of causes and treatment options. Nurse Pract 2013; 38 (10): 22-31.
  4. Nast A., Dreno B., Bettoli V. et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26 (1): 1-29.
  5. Tanghetti E.A. The Role of Inflammation in the Pathology of Acne. J ClinAesthetDermatol 2013 Sep; 6 (9): 27-35.
  6. Leeming J.P., Holland K.T., Cuncliffe W.J. The microbial colonization of inflamed acne vulgaris lesions. Br J Dermatol 1988; 118: 203-208.
  7. Khodaeiani E., Fouladi R.F., Yousefi N. et al. Efficacy of 2% metronidazole gel in moderate acne vulgaris. Indian J Dermatol. 2012 Jul; 57 (4): 279-81.
  8. Nishimuta K., Ito Y. Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. Arch Dermatol Res 2003; 294: 544-51.

Views

Abstract - 147

PDF (Russian) - 66

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies