Preview

Вестник дерматологии и венерологии

Расширенный поиск

ЭНТЕЗИТ И ПСОРИАТИЧЕСКАЯ ОНИХОПАТИЯ КАК ПРЕДРАСПОЛАГАЮЩИЕ ФАКТОРЫ ПСОРИАТИЧЕСКОГО АРТРИТА У ПАЦИЕНТОВ, БОЛЬНЫХ ПСОРИАЗОМ

https://doi.org/10.25208/0042-4609-2018-94-1-38-50

Полный текст:

Аннотация

Псориатический артрит — это псориатическая спондилоартропатия, которая встречается у 20–30 % пациентов с псориазом. Псориатический артрит влияет на качество жизни пациентов и приводит к инвалидизации чаще, чем кожная форма псориаза. Псориаз ногтевых пластин считается прогностическим фактором в развитии псориатического артрита. Энтезит, — это раннее воспалительное изменение, которое наблюдается при псориатическом артрите, а изменения в ногтевой пластине являются результатом тесной взаимосвязи между ногтем и энтезисом дистального межфалангового сухожилия разгибателя, одним из основных энтезийных элементов, пораженным при псориатическом артрите. Различные визуализирующие исследования показали, что среди пациентов с псориазом присутствует существенное число случаев недиагностированного псориатического артрита. Поскольку раннее выявление и лечение псориатического артрита могло бы в конечном счете позволить предотвратить клиническое и радиологическое развитие болезни, существует необходимость установить клинические параметры определения риска заболевания.

Об авторах

Т. Г. Сидорчик
Рижский университет имени Паула Страдыня
Россия

Татьяна Григорьевна Сидорчик — врач-дерматолог, венеролог, Рижский университет имени Паула Страдыня.

LV-1007 Латвия, Рига, ул. Дзирциема, д. 16



В. А. Линев
Рижский университет имени Паула Страдыня
Россия

Виктор Александрович Линев — научный сотрудник радиологической научной лаборатории.

LV-1083, Латвия, г. Рига, ул. Гарденес, д. 13



М. А. Радзыня
Рижский университет имени Паула Страдыня
Россия

Мая Алдовна Радзыня — доктор медицинских наук, старший научный сотрудник, директор радиологической научной.

LV-1083, Латвия, г. Рига, ул. Гарденес, д. 13



А. Я. Рубинс
Латвийский университет
Россия

Андрис Янович Рубинс — доктор медицинских наук, профессор, заведующий кафедрой дерматовенерологии медицинского факультета.

LV-1586, Латвия, г. Рига, б-р Райниса, д. 19



С. А. Рубинс
Латвийский университет
Россия

Силвестр Андрисович Рубинс — доктор медицинских наук, доцент кафедры дерматовенерологии медицинского факультета.

LV-1586, Латвия, г. Рига, б-р Райниса, д. 19



Список литературы

1. Dhir V., Aggarwal A. Psoriatic arthritis: a critical review. Clin Rev Allergy Immunol. 2013;44:141–148.

2. Langenbruch A., Radtke M. A., Krensel M., Jacobi A., Reich K., Augustin M. Nail involvement as a predictor of concomitant psoriatic arthritis in patients with psoriasis. Br J Dermatol. 2014;171:1123–1128.

3. Lai T. L., Pang H. T., Cheuk Y. Y., Yip M. L. Psoriatic nail involvement and its relationship with distal interphalangeal joint disease. Clin. Rheumatol. August 1, 2016;35(8):2031–2037.

4. Taylor W., Gladman D., Helliwell P., Marchesoni A., Mease P., Mielants H. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006;54:2665–2673.

5. Coates L. C., Conaghan P. G., Emery P., Green M. J., Ibrahim G., MacIver H. et al. Sensitivity and specificity of the classification of psoriatic arthritis criteria in early psoriatic arthritis. Arthritis Rheum. 2012;64:3150–3155.

6. Langenbruch A., Radtke M.A., Krensel M., Jacobi A., Reich K., Augustin M. Nail involvement as a predictor of concomitant psoriatic arthritis in patients with psoriasis. Br J Dermatol. 2014;171:1123–1128.

7. McGonagle D., Tan A. L., Benjamin M. The biomechanical link between skin and joint disease in psoriasis and psoriatic arthritis: what every dermatologist needs to know. Ann Rheum Dis. 2008;67:1–4.

8. Benjamin M., McGonagle D. Histopathologic changes at «synovio-entheseal complexes» suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis. Arthritis Rheum. 2007;56:3601–3609.

9. McGonagle D., Lories R.J., Tan A. L., Benjamin M. The concept of a «synovio-entheseal complex» and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum. 2007;56:2482–2491.

10. Sherlock J. P., Joyce-Shaikh B., Turner S. P., Chao C. C., Sathe M., Grein J. et al. IL-23 induces spondyloarthropathy by acting on ROR-gammat+ CD3+-CD4–-CD8–-entheseal resident T cells. Nat Med. 2012;18:1069–1076.

11. McGonagle D. Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. J Eur Acad Dermatol Venereol. 2009;23:9–13.

12. Queiro R., Gonzalez S., Alperi M., Alonso S., Lopez-Larrea C., Martinez-Borra J. et al. HLA-DR17 is associated with enthesitis in psoriatic arthritis. Joint Bone Spine. 2011;78:428–429.

13. Mandl P., Niedermayer D. S., Balint P. V. Ultrasound for enthesitis: handle with care! Ann Rheum Dis. 2012;71:477–479.

14. Lories R.J., Matthys P., de Vlam K., Derese I., Luyten F. P. Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis. Ann Rheum Dis. 2004;63:595–598.

15. Lories R. J., Derese I., de Bari C., Luyten F.P. Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum. 2007;56:489–497.

16. Braem K., Deroose C. M., Luyten F. P., Lories R.J. Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis. Arthritis Res Ther. 2012;14:R59.

17. Langenbruch A., Radtke M. A., Krensel M., Jacobi A., Reich K., Augustin M. Nail involvement as a predictor of concomitant psoriatic arthritis in patients with psoriasis. Br J Dermatol. 2014;171:1123–1128.

18. Sandre M. K., Rohekar S. Psoriatic arthritis and nail changes: exploring the relationship. Semin Arthritis Rheum. 2014;44:162–169.

19. Tan A. L., Benjamin M., Toumi H., Grainger A.J., Tanner S. F., Emery P. et al. The relationship between the extensor tendon enthesis and the nail in distal interphalangeal joint disease in psoriatic arthritis — a high-resolution MRI and histological study. Rheumatology (Oxford). 2007;46:253–256.

20. McGonagle D. Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. J Eur Acad Dermatol Venereol. 2009;23:9–13.

21. Frediani B., Falsetti P., Storri L., Allegri A., Bisogno S., Baldi F. et al. Ultrasound and clinical evaluation of quadricipital tendon enthesitis in patients with psoriatic arthritis and rheumatoid arthritis. Clin Rheumatol. 2002;21:294–298.

22. Marchesoni A., Atzeni F., Spadaro A., Lubrano E., Provenzano G., Cauli A. et al. Identification of the clinical features distinguishing psoriatic arthritis and fibromyalgia. J Rheumatol. 2012;39:849–855.

23. Eshed I., Bollow M., McGonagle D. G., Tan A. L., Althoff C. E., Asbach P. et al. MRI of enthesitis of the appendicular skeleton in spondyloarthritis. Ann Rheum Dis. 2007;66:1553–1559.

24. Tan A. L., Grainger A. J., Tanner S. F., Emery P., McGonagle D. A high-resolution magnetic resonance imaging study of distal interphalangeal joint arthropathy in psoriatic arthritis and osteoarthritis: are they the same? Arthritis Rheum. 2006;54:1328–1333.

25. Vlychou M., Koutroumpas A., Alexiou I., Fezoulidis I., Sakkas L. I. High-resolution ultrasonography and 3.0. Clin Rheumatol. 2013;undefined.

26. Mease P. J. Measures of psoriatic arthritis: Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesitis Index (LEI), Spondyloarthritis Research Consortium of Canada (SPARCC), Maastricht Ankylosing Spondylitis EnthesisScore (MASES), Leeds Dactylitis Index (LDI), Patient Global for Psoriatic Arthritis, Dermatology Life Quality Index (DLQI), Psoriatic Arthritis Quality of Life (PsAQOL), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Psoriatic Arthritis Response Criteria (PsARC), Psoriatic Arthritis Joint Activity Index (PsAJAI), Disease Activity in Psoriatic Arthritis (DAPSA), and Composite Psoriatic Disease Activity Index (CPDAI). Arthritis Care Res (Hoboken). 2011;63:S64–S85.

27. Kavanaugh A., van der Heijde D., McInnes I. B., Mease P., Krueger G. G., Gladman D. D. et al. Golimumab in psoriatic arthritis: one-year clinical efficacy, radiographic, and safety results from a phase III, randomized, placebo-controlled trial. Arthritis Rheum. 2012;64:2504–2517.

28. Maksymowych W. P., Mallon C., Morrow S., Shojania K., Olszynski W. P., Wong R. L. et al. Development and validation of the Spondyloarthritis Research Consortium of Canada (SPARCC) EnthesitisIndex. Ann Rheum Dis. 2009;68:948–953.

29. Healy P. J., Helliwell P. S. Measuring clinical enthesitis in psoriatic arthritis: assessment of existing measures and development of an instrument specific to psoriatic arthritis. Arthritis Rheum. 2008;59:686–691.

30. Gorman J. D., Sack K. E., Davis J. C. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med. 2002;346:1349–1356.

31. van der Heijde D., Braun J., Deodhar A., Inman R. D., Xu S., Mack M. E. et al. Comparison of three enthesitis indices in a multicentre, randomized, placebo-controlled trial of golimumab in ankylosing spondylitis (GO-RAISE). Rheumatology (Oxford). 2012;52:321–325.

32. Coates L. C., Helliwell P.S. Disease measurement — enthesitis, skin, nails, spine and dactylitis. Best Pract Res Clin Rheumatol. 2010;24:659–670.

33. Yasser R., Yasser E., Hanan D., Nashwa el S., Rasker J. J. Enthesitis in seronegative spondyloarthropathies with special attention to the knee joint by MRI: a step forward toward understanding disease pathogenesis. Clin Rheumatol. 2011;30:313–322.

34. Gandjbakhch F., Terslev L., Joshua F., Wakefield R. J., Naredo E., and D’Agostino M. A. Ultrasound in the evaluation of enthesitis: status and perspectives. Arthritis Res Ther. 2011;13:R188.

35. Taniguchi Y., Kumon Y., Takata T., Sano S., Ohnishi T., Nogami M. et al. Imaging assessment of enthesitis in spondyloarthritis. Ann Nucl Med. 2012;27:105–111.

36. Anandarajah A. Imaging in psoriatic arthritis. Clin Rev Allergy Immunol. 2012;44:157–165.

37. De Filippis L. G., Caliri A., Lo Gullo R., Bartolone S., Miceli G., Cannavo S. P. et al. Ultrasonography in the early diagnosis of psoriasisassociated enthesopathy. Int J Tissue React. 2005;27:159–162.

38. Bandinelli F., Prignano F., Bonciani D., Bartoli F., Collaku L., Candelieri A. et al. Ultrasound detects occult entheseal involvement in early psoriatic arthritis independently of clinical features and psoriasis severity. Clin Exp Rheumatol. 2013;31:219–224.

39. Freeston J. E., Coates L. C., Helliwell P. S., Hensor E. M., Wakefield R. J., Emery P. et al. Is there subclinical enthesitis in early psoriatic arthritis? A clinical comparison with power Doppler ultrasound. Arthritis Care Res (Hoboken). 2012;64:1617–1621.

40. Ostergaard M., Poggenborg R.P. Magnetic resonance imaging in psoriatic arthritis — update on current status and future perspectives: a report from the GRAPPA 2010 annual meeting. J Rheumatol. 2012;39:408–412.

41. Aydin S. Z., Bas E., Basci O., Filippucci E., Wakefield R. J., Celikel C. et al. Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis. Ann Rheum Dis. 2010;69:2165–2168.

42. Wiell C., Szkudlarek M., Hasselquist M., Moller J. M., Vestergaard A., Norregaard J. et al. Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis. Arthritis Res Ther. 2007;9:R119.

43. Solivetti F. M., Elia F., Teoli M., De Mutiis C., Chimenti S., Berardesca E. et al. Role of contrast-enhanced ultrasound in early diagnosis of psoriatic arthritis. Dermatology. 2010;220:25–31.

44. Kaeley G. S. Review of the use of ultrasound for the diagnosis and monitoring of enthesitis in psoriatic arthritis. Curr Rheumatol Rep. 2011;13:338–345.

45. Gutierrez M., Filippucci E., Grassi W., and Rosemffet M. Intratendinous power Doppler changes related to patient position in seronegative spondyloarthritis. J Rheumatol. 2010;37:1057–1059.

46. D’Agostino M. A. Role of ultrasound in the diagnostic work-up of spondyloarthritis. Curr Opin Rheumatol. 2012;24:375–379.

47. De Zordo T., Fink C., Feuchtner G. M. et al. Real-time sonoelastography findings in healthy Achilles tendons. AJR Am J Roentgenol. 2009;193:134–137.

48. Trombetti J. Sonoelastography and musculoskeletal imaging. http://www.dotmed.com/news/story/7760/?lang=en. Updated December 23, 2008. Accessed August 28, 2012.

49. Keen H. I., Mease P. J., Bingham C. O., Giles J. T., Kaeley G., and Conaghan P. G. Systematic review of MRI, ultrasound, and scintigraphy as outcome measures for structural pathology in interventional therapeutic studies of knee arthritis: focus on responsiveness. J Rheumatol. 2011;38:142–154.

50. D’Agostino M. A., Said-Nahal R., Hacquard-Bouder C., Brasseur J. L., Dougados M., and Breban M. Assessment of peripheral enthesitis in the spondylarthropathies by ultrasonography combined with power Doppler: a cross-sectional study. Arthritis Rheum. 2003;48:523–533.

51. Erdem C. Z., Tekin N. S., Sarikaya S., Erdem L. O., and Gulec S. MR imaging features of foot involvement in patients with psoriasis. Eur J Radiol. 2008;67:521–525.

52. Palazzi C., Lubrano E., D’Angelo S., and Olivieri I. Beyond early diagnosis: occult psoriatic arthritis. J Rheumatol. 2010;37:1556–1558.

53. Naredo E., Moller I., de Miguel E., Batlle-Gualda E., Acebes C., Brito E. et al. High prevalence of ultrasonographic synovitis and enthesopathy in patients with psoriasis without psoriatic arthritis: a prospective case–control study. Rheumatology (Oxford). 2011;50:1838–1848.

54. Gutierrez M., Filippucci E., De Angelis R., Salaffi F., Filosa G., Ruta S. et al. Subclinical entheseal involvement in patients with psoriasis: an ultrasound study. Semin Arthritis Rheum. 2011;40:407–412.

55. Ozcakar L., Cetin A., Inanici F., Kaymak B., Gurer C.K., and Kolemen F. Ultrasonographical evaluation of the Achilles’ tendon in psoriasis patients. Int J Dermatol. 2005;44:930–932.

56. Tinazzi I., McGonagle D., Biasi D., Confente S., Caimmi C., Girolomoni G. et al. Preliminary evidence that subclinical enthesopathy may predict psoriatic arthritis in patients with psoriasis. J Rheumatol. 2011;38:2691–2692.

57. Girolomoni G., Gisondi P. Psoriasis and systemic inflammation: underdiagnosed enthesopathy. J Eur Acad Dermatol Venereol. 2009;23:3–8.

58. D’Agostino M. A., Aegerter P., Bechara K., Salliot C., Judet O., Chimenti M. S. et al. How to diagnose spondyloarthritis early? Accuracy of peripheral enthesitis detection by power Doppler ultrasonography. Ann Rheum Dis. 2011;70:1433–1440.

59. Gladman D. D., Thavaneswaran A., Chandran V., and Cook R. J. Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease? Ann Rheum Dis. 2011;70:2152–2154.

60. Helliwell P. S., and Porter G. Sensitivity and specificity of plain radiographic features of peripheral enthesopathy at major sites in psoriatic arthritis. Skeletal Radiol. 2007;36:1061–1066.

61. Braun J., Rudwaleit M., Kary S., Kron M., Wong R.L., and Kupper H. Clinical manifestations and responsiveness to adalimumab are similar in patients with ankylosing spondylitis with and without concomitant psoriasis. Rheumatology (Oxford). 2010;49:1578–1589.

62. Love T. J., Gudbjornsson B., Gudjonsson J. E., and Valdimarsson H. Psoriatic arthritis in Reykjavik, Iceland: prevalence, demographics, and disease course. J Rheumatol. 2007;34:2082–2088.

63. de Carvalho H. M., Bortoluzzo A. B., Goncalves C. R., da Silva J. A., Ximenes A. C., Bertolo M. B. et al: Gender characterization in a large series of Brazilian patients with spondyloarthritis. ClinRheumatol. 2012;31:687–695.

64. Yang Q., Qu L., Tian H., Hu Y., Peng J., Yu X. et al. Prevalence and characteristics of psoriatic arthritis in Chinese patients with psoriasis. J Eur Acad Dermatol Venereol. 2011;25:1409–1414.

65. Aydin S. Z., Ash Z. R., Tinazzi I., Castillo-Gallego C., Kwok C., Wilson C. et al. The link between enthesitis and arthritis in psoriatic arthritis: a switch to a vascular phenotype at insertions may play a role in arthritis development. Ann Rheum Dis. 2012;undefined.

66. Delle Sedie A., Riente L., Filippucci E., Scire C.A., Iagnocco A., Gutierrez M. et al. Ultrasound imaging for the rheumatologist XXVI. Sonographic assessment of the knee in patients with psoriatic arthritis. Clin Exp Rheumatol. 2010;28:147–152.

67. Scarpa R., Cuocolo A., Peluso R., Atteno M., Gisonni P., Iervolino S. et al. Early psoriatic arthritis: the clinical spectrum. J Rheumatol. 2008;35:137–141.

68. Iagnocco A., Spadaro A., Marchesoni A., Cauli A., De Lucia O., Gabba A. et al. Power Doppler ultrasonographic evaluation of enthesitis in psoriatic arthritis. A multi-center study. Joint Bone Spine. 2012;79:324–325.

69. Gutierrez M., Filippucci E., Salaffi F., Di Geso L., and Grassi W. Differential diagnosis between rheumatoid arthritis and psoriatic arthritis: the value of ultrasound findings at metacarpophalangeal joints level. Ann Rheum Dis. 2011;70:1111–1114.

70. Marzo-Ortega H., Tanner S. F., Rhodes L. A., Tan A.L., Conaghan P. G., Hensor E. M. et al Magnetic resonance imaging in the assessment of metacarpophalangeal joint disease in early psoriatic and rheumatoid arthritis. Scand J Rheumatol. 2009;38:79–83.

71. Ibrahim G., Groves C., Chandramohan M., Beltran A., Valle R., Reyes B. et al. Clinical and ultrasound examination of the leeds enthesitis index in psoriatic arthritis and rheumatoid arthritis. ISRN Rheumatol. 2011;2011:731917.

72. Narvaez J., Narvaez J.A., de Albert M., Gomez-Vaquero C., and Nolla J.M. Can magnetic resonance imaging of the hand and wrist differentiate between rheumatoid arthritis and psoriatic arthritis in the early stages of the disease? Semin Arthritis Rheum. 2012;42:234–245.

73. Naredo E., Batlle-Gualda E., Garcia-Vivar M. L., Garcia-Aparicio A. M., Fernandez-Sueiro J. L., Fernandez-Prada M. et al. Power Doppler ultrasonography assessment of entheses in spondyloarthropathies: response to therapy of entheseal abnormalities. J Rheumatol. 2010;37:2110–2117.

74. Brockbank J. E., Stein M., Schentag C. T., and Gladman D. D. Dactylitis in psoriatic arthritis: a marker for disease severity? Ann Rheum Dis. 2005;64:188–190.

75. Mumtaz A., Gallagher P., Kirby B., Waxman R., Coates L.C., Veale J. D. et al. Development of a preliminary composite disease activity index in psoriatic arthritis. Ann Rheum Dis. 2011;70:272–277.

76. FitzGerald O., Helliwell P., Mease P., Mumtaz A., Coates L., Peder- sen R. et al. Application of composite disease activity scores in psoriatic arthritis to the PRESTA data set. Ann Rheum Dis. 2012;71:358–362.

77. Coates L. C., Fransen J., and Helliwell P. S. Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment. Ann Rheum Dis. 2010;69:48–53.

78. Baranauskaite A., Raffayova H., Kungurov N. V., Kubanova A., Venalis A., Helmle L. et al. Infliximab plus methotrexate is superior to methotrexate alone in the treatment of psoriatic arthritis in methotrexate-naive patients: the RESPOND study. Ann Rheum Dis. 2012;71:541–548.

79. Kingsley G. H., Kowalczyk A., Taylor H., Ibrahim F., Packham J. C., McHugh N. J. et al. A randomized placebo-controlled trial of methotrexate in psoriatic arthritis. Rheumatology (Oxford). 2012;51:1368–1377.

80. Marchesoni A., Altomare G., Matucci-Cerinic M., Balato N., Olivieri I., Salvarani C. et al. An Italian shared dermatological and rheumatological proposal for the use of biological agents in psoriatic disease. J Eur Acad Dermatol Venereol. 2010;24:578–586.

81. Gossec L., Smolen J.S., Gaujoux-Viala C., Ash Z., Marzo-Ortega H., van der Heijde D. et al. European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis. 2012;71:4–12.

82. Ritchlin C. T., Kavanaugh A., Gladman D. D., Mease P. J., Helliwell P., Boehncke W. H. et al. Treatment recommendations for psoriatic arthritis. Ann Rheum Dis. 2009;68:1387–1394.

83. Kavanaugh A., McInnes I., Mease P., Krueger G. G., Gladman D., Gomez-Reino J. et al. Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: twenty-four-week efficacy and safety results of a randomized, placebo-controlled study. Arthritis Rheum. 2009;60:976–986.

84. Gladman D. D., Sampalis J. S., Illouz O., and Guerette B. Responses to adalimumab in patients with active psoriatic arthritis who have not adequately responded to prior therapy: effectiveness and safety results from an open-label study. J Rheumatol. 2010;37:1898–1906.

85. Kavanaugh A., Mease P. Treatment of psoriatic arthritis with tumor necrosis factor inhibitors: longer-term outcomes including enthesitis and dactylitis with golimumab treatment in the LongtermExtension of a Randomized, Placebo-controlled Study (GO-REVEAL). J Rheumatol. 2012;89:90–93.

86. Sterry W., Ortonne J. P., Kirkham B., Brocq O., Robertson D., Peder- sen R. D. et al. Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trial. Br Med J. 2010;340:147.

87. Milia A. F., Ibba-Manneschi L., Manetti M., Benelli G., Generini S., Messerini L. et al. Evidence for the prevention of enthesitis in HLA-B27/ hbeta(2)m transgenic rats treated with a monoclonal antibody against TNF-alpha. J Cell Mol Med. 2011;15:270–279.

88. Gottlieb A., Menter A., Mendelsohn A., Shen Y. K., Li S., Guzzo C. et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet. 2009;373:633–640.


Для цитирования:


Сидорчик Т.Г., Линев В.А., Радзыня М.А., Рубинс А.Я., Рубинс С.А. ЭНТЕЗИТ И ПСОРИАТИЧЕСКАЯ ОНИХОПАТИЯ КАК ПРЕДРАСПОЛАГАЮЩИЕ ФАКТОРЫ ПСОРИАТИЧЕСКОГО АРТРИТА У ПАЦИЕНТОВ, БОЛЬНЫХ ПСОРИАЗОМ. Вестник дерматологии и венерологии. 2018;94(1):38-50. https://doi.org/10.25208/0042-4609-2018-94-1-38-50

For citation:


Sidorcika T.G., Linovs V.A., Radzina M.A., Rubins A.J., Rubins S.A. ENTHESITIS AND PSORIATIC ONYCHOPATHY AS A FACTOR FOR PREDICTION OF PSORIATIC ARTHRITIS IN PSORIASIS. Vestnik dermatologii i venerologii. 2018;94(1):38-50. (In Russ.) https://doi.org/10.25208/0042-4609-2018-94-1-38-50

Просмотров: 999


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 0042-4609 (Print)
ISSN 2313-6294 (Online)