Genetic variants of U. parvum and their role in the development of inflammatory diseases of the urogenital system

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Abstract


The article discusses the results of a study aimed at determining the frequency of different genetic variants of U. parvum in women with inflammatory diseases of the urogenital system and clinically healthy subjects. Molecular typing of 40 samples of U. parvum taken from women with different forms of inflammatory diseases of the urogenital system was performed for the mba gene. The authors revealed a relationship between clinical manifestations of inflammatory diseases of the urogenital system caused by U. parvum and different U. parvum serovars. An infection with 6 U. parvum serovar results in the development of inflammatory processes in the form of cervicitis or vaginitis accompanied by subjective manifestations more frequently than an infection with other serovars under examination (1 and 3) (p < 0.05).

M. R. Rakhmatullina

State Research Center of Dermatovenereology and Cosmetology, Ministry of healthcare of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru

Russian Federation

K. I. Plakhova

State Research Center of Dermatovenereology and Cosmetology, Ministry of healthcare of the Russian Federation

Email: plahova_xenia@mail.ru

Russian Federation

O. N. Igonina

State Research Center of Dermatovenereology and Cosmetology, Ministry of healthcare of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

  1. Yamazaki T., Matsumoto M., Matsuo J., Abe K., Minami K., Yamaguchi H. Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan.BMC Infect Dis 2012; 12: 82. doi: 10.1186/1471- 2334-12-82
  2. De Francesco M.A., Negrini R., Pinsi G., Peroni L., Manca N.: Detection of Ureaplasma biovars and polymerase chain reaction-based subtyping of Ureaplasma parvum in women with or without symptoms of genital infections. Eur J ClinMicrobiol Infect Dis 2009; 28: 641-646.
  3. Zdrodowska-Stefanow B., Klosowska W.M, Ostaszewska-Puchalska I., Bulhak-Koziol V., Kotowicz B. Ureaplasma urealyticum and Mycoplasma hominis infection in women with urogenital diseases. Advances in Medical Sciences 2006; 51: 250-253. 84 к № 3, 2014
  4. Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature 2000; 407: 757-762.
  5. Peterson S.N., Fraser C. M.The complexity of simplicity. Genome Biology. USA 2001, 2.
  6. Woese C.R., Maniloff J., Zablen L.B.: Phylogenetic analysis of the mycoplasmas. ProcNat-lAcadSci USA 1980; 77: 494-498.
  7. Борхсениус С.Н., Чернова О.А., Чернов В.М., Вонский М.С. Микоплазмы. Молекулярная и клеточная биология, взаимодействие с иммунной системой млекопитающих, патогенность, диагностика. СПб: Наука 2002; 319.
  8. Teng, L.J., Zheng, X., Glass J.I., Watson H.L., Tsai 1. &Cassell G.H. Ureaplasma urealyticum biovar specificity and diversity are encoded in multiple banded antigen gene. J ClinMicrobiol 1994, 32: 1464-1469.
  9. Dando S.J., Nitsos I., Kallapur S.G., Newnham J.P., Polglase G.R., Pillow J.J., Jobe A.H., Timms P., Knox C.L. The role of the multiple banded antigen of Ureaplasma parvum in intra-amniotic infection: major virulence factor or decoy? PLoS One. 2012; 7 (1): 29856.
  10. Zheng X., Teng L.J., Watson H.L., Glass J.I., Blanchard A, et al. Small repeating units within the Ureaplasma urealyticum MB antigen gene encode serovar specificity and are associated with antigen size variation. Infect Immun 1995; 63: 891-898.
  11. Kong F., Ma Z., James G., Gordon S., Gilbert G.L. Molecular genotyping of human Ureaplasma species based on multiple-banded antigen (MBA) gene sequences.Int J SystEvol-Microbiol 2000; 50 Pt 5: 1921-1929.
  12. Kaspzykowska U., Elias J., Elias M. Colonization of the lower urogenital tract with Ureaplsama pasvum can couse asymptomatic infection of the upper reproductive system in women: a preliminary study. Arch Gynecol Obstet 2014 May; 289 (5): 1129-34.
  13. Payne M.S., Tabone T., Kemp M.W., Keelan J.A., Spiller O.B., Newnham J.P. Highresolution melt PCR analysis for genotyping of Ureaplasma parvum isolates directly from clinical samples. J Clin Microbiol. 2014 Feb; 52 (2): 599-606. doi: 10.1128/JCM.03036-13. Epub 2013 Dec 11.
  14. De Francesco M.A., Negrimi R., Pinsi G., Peroni L., Manca M. Ureaplasma biovars and polymerase chain reaction-based subtyping of Ureaplasma parvum in women with or without symptoms of genital infections. Eur J Clin Microbiol Infect Dis. 2009; 28: 641-646.
  15. Kong F., Ma I., James G., Gordon S., Gilbert G.L. Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays. J Clin Microbiol. 2000; 38 (3): 1175-1179.

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