Skin lesion at acute monoblastic leukemia (clinical observation)

Cover Page

Abstract


At present diagnosis of acute leukemia does not represent any difficulties and is based on morphological and immunophenotypical bone marrow studies. The paper presents a non-standard verification algorithm of acute monoblastic leukemia in elderly female patient, with leukemic skin lesion. Morphologic and immunohistochemical studies of biopsy materials of skin, lymph node and bone marrow allow establishing a linear membership of tumor cells and promptly verifying the diagnosis of leukemia. Lack of the overall clinical examination in such cases leads to diagnostic errors and to late verification of the true diagnosis and significantly worsens the prognosis.

About the authors

N. G. Chernova

Hematological Scientific Center

Author for correspondence.
Email: ngchernova@mail.ru

Russian Federation

M. N. Sinicyna

Hematological Scientific Center

Email: noemail@neicon.ru

Russian Federation

V. N. Dvirnyk

Hematological Scientific Center

Email: noemail@neicon.ru

Russian Federation

A. M. Kovrigina

Hematological Scientific Center

Email: noemail@neicon.ru

Russian Federation

E. E. Zvonkov

Hematological Scientific Center

Email: noemail@neicon.ru

Russian Federation

E. N. Parovichnikova

Hematological Scientific Center

Email: noemail@neicon.ru

Russian Federation

References

  1. Swerdlow S. H., Campo E., Harris N. L., Jaffe E. S., Pileri S. A., Stein H., Thiele J., Vardiman J. W. WHO classification of tumor of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.
  2. Savchenko V. G., Parovichnikova E. N., Afanasyev B. V., Gritsayev S. V., Semochkin S. V., Bondarenko S. N., Troitskaya V. V., Sokolov A. N., Kuzmina L. A., Klyasova G. A., Gaponova T. V., Baranova O.Yu., Lapin V. A., Konstantinova T. S., Samoylova O. S., Kaporskaya T. S., Shatokhin S. V. Natsionalnyye klinicheskiye rekomendatsii po diagnostike i lecheniyu ostrykh miyeloidnykh leykozov vzroslykh. Gematologiya i transfuziologiya. 2014. T. 59. N S2. S. 2-29. [Савченко В. Г., Паровичникова Е. Н., Афанасьев Б. В., Грицаев С. В., Семочкин С. В., Бондаренко С. Н., Троицкая В. В., Соколов А. Н., Кузьмина Л. А., Клясова Г. А., Гапонова Т. В., Баранова О. Ю., Лапин В. А., Константинова Т. С., Самойлова О. С., Капорская Т. С., Шатохин С. В. Национальные клинические рекомендации по диагностике и лечению острых миелоидных лейкозов взрослых. Гематология и трансфузиология. 2014. Т. 59. N S2. С. 2-29]
  3. Cho-Vega J. H., Medeiros L. J., Prieto V. G., Vega F. Leukemia cutis Am J Clin Pathol. 2008 Jan;129(1):130-42. doi: 10.1309/WYACYWF-6NGM3WBRT.
  4. Chang H., Brandwein J., Yi Q. L., Chun K., Patterson B., Brien B. Extramedullary infiltrates of AML areassociated with CD56 expression, 11q23 abnormalites and inferior clinical outcome. Leuk Res. 2004 Oct; 28(10):1007-11. doi: 10.1016/j.leukres.2004.01.006.
  5. Agis H., Weltermann A., Fonatsch C., Haas O., Mitterbauer G., Mullauer L., Schrei-ber S., Schwarzinger I., Juretzka W., Valent P., Jager U., Lechner K., Geissler K. A comparative study on demographic, histological and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis. Ann Hematol 2002 Feb; 81(2): 90- 5. doi: 10.1007/s00277-001-0412-9.
  6. Rukavitsyn A. O., Lamotkin I. A., Antipova A. S. Kharakteristika spetsificheskikh porazheniy kozhi pri ostrykh leykozakh. Gematologiya. Transfuziologiya. Vostochnaya Evropa. № 2 (02). 2015. S. 135-141. [Рукавицын А. О., Ламоткин И. А., Антипова А. С. Характеристика специфических поражений кожи при острых лейкозах. Гематология. Трансфузиология. Восточная Европа. № 2 (02). 2015. С. 135-141.]
  7. Long J. C., Mihm M. C. Multiple granulocytic tumors of the skin: report of six cases of myelogenous leukemia with initial manifestations in the skin. Cancer 1977 May; 39 (5): 2004-16.
  8. Faaij C. M., Willemze A. J., Revesz T., et al. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7. Pediatr Blood Cancer 2010:55; 344-348. doi: 10.1002/pbc.22500.
  9. Sharma S. K, Gupta S., Seth T., Mishra P., Mahapatra M., Singh M. K., Gupta S. Leukemia Cutis: An Unusual Presentation Indian J Hematol Blood Transfus. Sep 2012; 28 (3): 175-177. doi: 10.1007/s12288-011-0113-z.
  10. Martinez-Escaname M., Zuriel D., Tee S. I., Fried I., Massone C., Cerroni L. Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses. Am J Dermatopathol 2013 Jun; 35 (4): 419-24. doi: 10.1097/DAD.0b013e31826ffe6f.
  11. Kaddu S., Zenahlik P., Beham-Schmid C., Kerl H., Cerroni L. Specific cutaneous infiltrates in patients with myelogenous leukemia: A clini-copathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 1999 Jun; 40 (6 Pt 1): 966-78.
  12. Byrd J. C., Weiss R. B., Arthur D. C., Lawrence D., Baer M. R., Davey F., Trikha E. S., Carroll A. J., Tantravahi R., Qumsiyeh M., Patil S. R., Moore J. O., Mayer R. J., Schiffer C. A., Bloomfield C. D. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. J Clin Oncol 1997 Feb; 15 (2): 466-75.

Statistics

Views

Abstract - 467

PDF (Russian) - 609

PlumX

Dimensions


Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies