Feasibility of combination the outer antibakterialnoy therapy and preparation azelaic acid for treatment of acne

Cover Page

Abstract


The review presents modern views on the pathogenesis of acne. The data of foreign and domestic clinical trials to study the efficacy and safety of drugs containing 1% clindamycin and 15% azelaic acid used to treat acne. The mechanisms of the effects of these drugs on the main elements of the pathogenesis of acne. Substantiates the appropriateness of the drug combination of clindamycin and azelaic acid in the treatment of acne patients.

D. K. Dombrovskaya

Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: zakomarik@gmail.com

Russian Federation

K. N. Monakhov

Pavlov First Saint Petersburg State Medical University

Email: zakomarik@gmail.com

Russian Federation

  1. Dawson A.L., Dellavalle R. P. acne vulgaris. BMJ. 2013 May 8. 346:2634. doi: 10.1136/bmj.f2634.
  2. Shinjita Das; Rachel V. Reynolds. Recent Advances in Acne Pathogenesis. Implications for Therapy. Am J Clin Dermatol 2014;15(6):479-488. doi: 10.1007/s40257-014-0099-z.
  3. Akne i rozatsea. Pod red. prof. N.N. Potekaeva. M: Binom 2007; 216, il.
  4. Samtsov A.V. Akne i akneformnyie dermatozyi M, 2009: 287.
  5. Rukovodstvo po dermatokosmetologii. Pod red. E.R. Araviyskoy, E.V. Sokolovskogo. SPb: Foliant 2008; 632: il
  6. Jaggi Rao, MD, FRCPC; Chief Editor: William D. James, MD Acne Vulgaris. Practice Essentials. May 20, 2016. [Medscape]
  7. McInturff J.E., Modlin R.L., Kim J. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease. J Invest Dermatol 2005 Jul; 125(1):1-8.
  8. Jugeau S., Tenaud I., Knol A.C., Jarrousse V., Quereux G., Khammari A. et al. Induction of tolllike receptors by Propionibacteriumacnes. Br J Dermatol 2005;153(6):1105-13.
  9. Kim J. Review of the innate immune response in acne vulgaris: activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. Dermatol Basel Switz 2005; 211(3):193-8.
  10. Selway J.L., Kurczab T., Kealey T., Langlands K. Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. BMC Dermatol 2013; 13:10 doi: 10.1186/14715945-13-10.
  11. Thiboutot D. Regulation of human sebaceous glands. J Invest Dermatol 2004; 123(1):1-12
  12. Kabaeva T.I. Complex diagnostics using gas chromatography-mass spectrometry of the composition of sebum, microecology skin and intestine in patients with acne. Clin Lab 2004; 9:65-66
  13. Guidelines of care for the management of acne vulgaris. J Am AcadDermatol 2016 Feb 15.pii: S0190-9622(15)02614-6. doi: 10.1016/j. jaad.2015.12.037.
  14. Federalnyie klinicheskie rekomendatsii po vedeniyu bolnyih akne. Rossiyskoe obschestvo dermatovenerologov i kosmetologov 2015
  15. Kungurov N.V., Kohan M.M., Shabardina O. et al. Experience in the use of a new drug azelaic acid - gel skinoren - in the treatment of acne. Clin Dermatol Venereol: scientific journal. M: Charity Central 2005; 1: 31-36
  16. Chien A.L., Qi J., Rainer B., Sachs D.L., Helfrich Y.R. Treatment of Acne in Pregnancy. J Am Board Fam Med 2016 March-April; 29 (2): 254-62. doi: 10.3122/jabfm.2016.02.150165
  17. Samtsov A.V. Topicheskie antibiotiki v lechenii akne. Vestn dermatol venerol 2011; 1: 84-85
  18. Monahov K.N., Dombrovskaya D.K. Acne Therapy: azelaic acid and basic care. Vestn Dermatol Venereol 2015; (4): 113-118
  19. Tirgar et al. Iranian Comparison of the Effect of Azelaic Acid 20% And Clindamycin 1% In the Treatment of Mild And Moderate Acne. J Dermatol 2009 Iranian Society of Dermatology, p. 106-110.
  20. Pazoki-Toroudi H., Nilforoushzadeh M.A., Ajami M. et al. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Cutan Ocul Toxicol. 2011 Dec; 30 (4): 286-91 doi: 10.3109/15569527.2011.581257. Epub 2011 May 25.
  21. Kondratieva Y.S., Shepileva T.N., Kokina O.A., Subbotin E.A. Comparative analysis of the efficacy of combined topical treatment of patients with papules, pustular form of acne. Vestn Dermatol Venerol 2015; 3: 135-140
  22. Hardikova S.A. Kazantseva E.V. Aripova M.L. Open comparative study on the effectiveness of and safety of 15% azelaic acid gel, adapalene gel 0.1%, 1% clindamycin gel in combination treatment of patients with papules, pustular form of mild to moderate acne Klin dermatol venerol. 2016; 2: 51-56 doi: 10.17116/ klinderma2016152

Views

Abstract - 77

PDF (Russian) - 21

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies