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Селективное внутриклеточное ингибирование сигнальных путей - новое направление системной терапии больных псориазом

https://doi.org/10.25208/0042-4609-2016-0-5-142-149

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Аннотация

В статье приводятся современные данные литературы о новом направлении системной терапии пациентов с псориазом с помощью «малых молекул», которые действуют внутриклеточно, селективно ингибируя сигнальные пути, отвечающие за выработку ключевых про- и противовоспалительных медиаторов, играющих важную роль в патофизиологии псориаза. Обсуждаются ключевые вопросы иммунопатогенеза псориаза, таргетного влияния «малых молекул» на ключевые компоненты врожденного и адаптивного иммунитета при псориазе. Представлены результаты исследований, выполненных с использованием принципов доказательной медицины, эффективности и безопасности апремиласта - первого и единственного на сегодняшний день селективного ингибитора внутриклеточной фосфодиэстеразы 4 - при среднетяжелом и тяжелом псориазе, в том числе у пациентов с проблемными локализациями дерматоза (псориаз волосистой части головы, ладоней, подошв, ногтевых пластин) и в долгосрочной перспективе. Показано, что непрерывная терапия апремиластом в сроки от 52 до 156 недель сопровождалась достоверным уменьшением распространенности и тяжести псориаза. Нежелательные явления регистрировались редко, протекали в легкой форме, а частота серьезных нежелательных явлений была сопоставима с плацебо.

Об авторе

А. Л. Бакулев
ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России
Россия


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Для цитирования:


Бакулев А.Л. Селективное внутриклеточное ингибирование сигнальных путей - новое направление системной терапии больных псориазом. Вестник дерматологии и венерологии. 2016;(5):55-62. https://doi.org/10.25208/0042-4609-2016-0-5-142-149

For citation:


Bakulev A.L. Selective intracellular inhibition of signalling pathways - new direction in systematic treatment of psoriasis patients. Vestnik dermatologii i venerologii. 2016;(5):55-62. (In Russ.) https://doi.org/10.25208/0042-4609-2016-0-5-142-149

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