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Вестник дерматологии и венерологии

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Иммунный патогенез псориаза

https://doi.org/10.25208/0042-4609-2016-0-4-30-33

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Аннотация

Представлены современные сведения об иммунных механизмах развития псориаза. Воспаление в коже больных псориазом рассматривается как аутоиммунный процесс, в котором ключевую роль играют сенсибилизированные к кератиноцитам Т-лимфоциты. Одним из наиболее вероятных аутоантигенов, инициирующих иммунное воспаление при псориазе, может являться цитозольная ДНК. Описаны функции отдельных субпопуляций иммунных клеток и эффекты секретируемых ими цитокинов в патогенезе псориаза: дендритных клеток - клеток Лангерганса, плазмацитоидных дендритных клеток, CD11c+ дендритных клеток; Т-лимфоцитов - Т-хелперов 1-го и 17-го типов, цитотоксических Т-лимфоцитов, Т-регуляторных лимфоцитов. Важная роль в развитии рецидивов псориаза отводится формированию в коже больных Т-клеточной памяти и интрадермальной пролиферации Т-лимфоцитов.

Об авторах

В. Р. Хайрутдинов
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Россия


И. Э. Белоусова
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Россия


А. В. Самцов
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Россия


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Для цитирования:


Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В. Иммунный патогенез псориаза. Вестник дерматологии и венерологии. 2016;(4):20-26. https://doi.org/10.25208/0042-4609-2016-0-4-30-33

For citation:


Khairutdinov V.R., Belousova I.E., Samtsov A.V. Immune pathogenesis of psoriasis. Vestnik dermatologii i venerologii. 2016;(4):20-26. (In Russ.) https://doi.org/10.25208/0042-4609-2016-0-4-30-33

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ISSN 0042-4609 (Print)
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