Osteoporosis as a result of the long-term administration of glucocorticoids in patients suffering from acantholytic pemphigus

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Abstract


Goal. To study the prevalence of glucocorticoid-induced osteoporosis in patients suffering from acantholytic pemphigus and risk of osteoporosis-related fractures. Materials and methods. The study involved 26 patients including 12 patients suffering from acantholytic pemphigus. The patients underwent dual-energy X-ray absorptiometry (DXA) for calculating bone mineral density (BMD) as well as T and Z scores. To assess the ten-year probability (absolute risk) of fractures, the FRAX model was applied. Major results. Glucocorticoid-induced osteoporosis was diagnosed in 33.3% of the AP patients receiving a glucocorticoid therapy, and osteopenia was also diagnosed in 33.3% of them; an increased risk of osteoporosis-related fractures was observed in all of the patients over 40, which entails the need in early diagnostics of pathologic bone changes and prevention of complications such as osteoporosis-related fractures. Conclusion. A high share of complications (83.3%) related to systemic GCS stipulates the need in increased cooperation between dermatologists and allied specialists.

M. A. Ufimtseva

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: mail-m@mail.ru

Russian Federation

YU. M. Bochkarev

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

E. P. Gurkovskaya

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

P. S. Puhtinskaya

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

K. I. Nikolaeva

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

O. D. Lesnaya

State budget educational institution of higher professional education "Ural State Medical University" of the Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

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