The role of bacterial infection in the pathogenesis of psoriasis

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Abstract


The article presents the results of numerous studies confirming the involvement of bacterial agents in the psoriatic process manifestation as triggering factors. The article discusses potential pathogenic mechanisms of the participation of bacterial superantigens in the initiation of a cascade of immunological reactions resulting in the hyperproliferation of keratinocytes. The expediency of using antibacterial agents as a part of a complex therapy of different forms of the disease is discussed.

About the authors

N. A. Slesarenko

Saratov State Medical University named after V.I. Rasumovsky

Author for correspondence.
Email: noemail@neicon.ru

Russian Federation

S. R. Utz

Saratov State Medical University named after V.I. Rasumovsky

Email: s_utz@mail.ru

Russian Federation

References

  1. Кубанова А.А., Катунина О.Р. Иммуноморфология и морфогенез очагов пораженной кожи при псориазе. Вестн дерматол венерол 2010; (1): 70-79
  2. Nestle F.O., Kaplan D.H., Barker J. Psoriasis. New Engl J Med 2009; (5): 496-509.
  3. Sano S, Chan KS, Carbajal S. et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 2005; (11): 43-49.
  4. Рекен М., Шаллер М., Заттлер Э., Бургдорф В. Атлас по дерматологии. Москва: Пресс-информ 2014.
  5. Fry L., Baker B.S. Triggering psoriasis: the role of infections and medications. Clin Dermatol 2007; (25): 606-615.
  6. Williams M.L., Elias P.M. From basket weave to barrier: unifying concepts for the disorders of cornification. Arch Dermatol 1993; (129): 626-629.
  7. Novelli L, Chimenti M., Chiricozzi A., Perricone R. The new era for the treatment of psoriasis and psoriatic arthritis: Perspectives and validated strategies Autoimmunity Reviews 2014; (13): 1-69.
  8. Wolf R., Orion E., Ruocco E., Ruocco V. Abnormal epidermal barrier in the pathogenesis of psoriasis. Clin Dermatology 2012; (30): 323-328.
  9. Hebborn P., Jablonska S., Beutner E. H., Langner A. Action of topically applied arachidonic acid on the skin of patients with psoriasis. Arch Dermatol 1988: 124 (3); 387-391.
  10. Zenz R., Eferi R., Kenner L. et al. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 2005; (437): 369-375
  11. Катунина О.Р., Резайкина А.В. Свременные представления об участии кожи в иммунных процессах. Вестник дерматологии и венерологии. 2009; (2): 39-36
  12. Тюрин Ю.А., Мустафин И.Г., Фассахов Р.С. Природная устойчивость бактерий к факторам врожденной иммунной системы, обусловленная бактериальными протеазами. Практич мед. казань 2010; 1: 7 - 13
  13. Mansson A., Adrier M., Cardell L.Q. Toll-like receptors in cellular subsets of human tonsil T-cells: altered expression during recurrent tonsillitis. Respir Res 2006; (7): 36-7.
  14. Owen C.M., Chalmers R.J. O’Sullivan T., Griffiths C.E. A systematic review of antistreptococcal interventions for guttate and chronic plaque psoriasis. Br J Dermatol 2001; (145): 886-90.
  15. McFadden J., Fry L., Powles A.V., Kimber I. Concepts in psoriasis: psoriasis and the extracellular matrix. Brit J Dermatology 2012; (167): 980-986.
  16. Scheinfeld G.J. Fungus and autoimmune diseases. Int Med J 1998; 11-12: 971-974.
  17. Valdimarsson H., Thorleifsdottir R.H., Sigurdar-dottir S.L. et al. Psoriasis - as an autoimmune disease caused by molecular mimicry. Trends Immunology 2009; (10): 494-501.
  18. Grozdev I., Korman N., Tsankov N. Psoriasis as a systemic disease. Clin Dermatol 2014; 32 (3): 343-350.
  19. Prinz J.C. Disease mimicry - a phatogenetic concepts for T-cell-mediated autoimmune disorders triggered by molecular mimicry. Autoimmun Rev 2004; (3): 10-15.
  20. Weisenseel P., Prinz J.C. Incidental detection of S. pyogenes-DNA in psoriatic skin by PCR. Arch dermatol res 2005; 296 (12): 573-576.
  21. Macias E., F. Pereira F., Rietkerk W., Safai B. Superantigens in dermatology. J Am Acad Dermatology 2011; (4): 455-472.
  22. Тлиш M.M., Сычева Н.Л., Фаустов Л.А. Клинико-морфологические особенности каплевидного псориаза. Клин дерматол и венерол 2012; (5): 65-70
  23. Reich A., Batycka-Baran A. New Insights into the Pathogenesis of Psoriasis. Eur Dermatol 2010; 5: 10-15.
  24. Ryan C., Korman N.J., Gelfand J. M. et al. Research gaps in psoriasis: Opportunities for future studies. J Acad Dermatol 2014; 70 (1): 1-20.
  25. Clarke L.E., Helni K.F., Hennessy J., Clark J.T. Dermal dendritic cell in psoriasis, dermatitis and normal skin. J Am Acad Dermatol 2011; 64 (3): 464-472.
  26. Leung D., Travers J., Giorno R.D. et al. Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. J Clin Invest 1995, 96 (5): 2106-2112.
  27. Бухова В.П., Базанова Е.А., Бородиюк Н.А. Обнаружение детерминанты общей для полисахарида стрептококка группы А, стафилококка и эпидермального антигена эпителия тимуса. Рос журн кожн и венерич болезней. 1996; 4: 19-21
  28. Маянский А.Н. Стрептококки: микробиология и патология. Вопр диагност в педиатр 2010; .2 (1): 9-20
  29. Rosenberg E.W., Patricia W.N., Skinner R.B. Microorganisms and psoriasis. J National Medical Ass 2009; 86: 4; 305-310
  30. Иванов О.Л., Мареева Е.Б. Неспецифический ги-перэргический синдром. Рос журн кожн вен болезней 2010; (4): 4-10
  31. Jappe U. Superantigens and their association with dermatological inflammatory diseases: facts and hypotheses. Acta dermato-venereologica 2000; 80 (5): 321-328.
  32. England R., Straachan D., KnightT, L. Streptococcal tonsillitis and its association with psoriasis: a review. Clinical Otolaryngology & Allied Sciences 1997; (10): 532-535.
  33. Mc Milln D.L., Richards D.G., Mein E.A., Nelson C.D. Systemic aspects of psoriasis: an integrative model based on intestinal etiology. Int Med 1999; (2/3): 105-113
  34. Gudjonsson J., Thorarinsson A., Sigurgeirs-son B., Kristinsson K. Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study. British Journal of Dermatology 2003; (149): 530-534.
  35. Sigurdardottir S.L, Thorleifsdottir R.H., Valdimars-son H., Johnston A. The role palatine tonsils in the pathogenesis and treatment of psoriasis. Brit J Dermatol 2013; (168): 337-242.
  36. Крюков А.И., Товмасян А.С., Драбкина И.В., Сухина М.А., Жу-ховицкий В.Г. Роль микрофлоры в этиологии хронического тонзиллита. Вестн оториноларин-гол 2010; (3): 4-6
  37. Duglas R., Main E., Mac-Millin D., Nelson K. Systemic aspects of psoriasis: an integrative model based on intestinal etiology. Integrative Medicine, 2000; (2) : 105-119
  38. Пегано Д. Лечение псориаза. Естественный путь. М, 2001
  39. Короткий Н.Г., Песляк М.Ю. Псориаз как следствие включения ß-стрептококков в микробиоценоз кишечника с повышенной проницаемостью (концепция патогенеза). Вестн дерматол венерол 2005; (1): 9-18
  40. Лиходед В.Г., Ющук Н.Д., Яковлев М.Ю. Роль эндотоксина грамотрица-тельных бактерий в инфекционной и неинфекционной патологии. Архив патологии 1996; (2): 8-13
  41. Ramirez-Boscâ A. et al. Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis.JAMA dermatology 2015.
  42. Mansood Q., Manzoor S., Rukhsana A. Treatment of acute guttate psoriasis with rifampicin. Indian J Dermatol Venereol Leprol 2000; (66): 296-298.
  43. Wilson J.K., Sami B.S., Al-Suwaidan N., Krow-chuk D., Feldman S.R. Treatment of psoriasis in children: is there a role for antibiotic therapy and tonsillectomy? Pediatric Dermatology 2003; (20): 11-15.
  44. Jager M., Jong E., van de Kerkhof et al. Efficacy and safety of childhood psoriasis: A systematic literature revive. J Am Acad Dermatol 2010; 62 (6): 1013-1030.
  45. Mesinkovska N.A., Tomecki K.J. Novel systemic antibiotics in dermatology. Dermatologic Therapy 2012; (25): 1-5.
  46. Rosenberg E.W., Noah P.W., Skinner R.B. Treatment of psoriasis with antimicrobial agents. In: Roenigk H.H., Maibach H.J. eds. Psoriasis. New York: Marcel Dekker 1965: 505-511.
  47. Rosenberg E.W., Skinner R.B., Noah P.W. Anti-infectious therapy in psoriasis, in: Psoriasis (Roenigk HH, Maibach HI, eds), 3rd edn. I New York: Marcel Dekker 1998; (1): 373-379.
  48. Вулф К., Джонсон Р., Сюр-монд Д. Дерматология по Томасу Фицпатрику: атлас-справочник. М: Практика 2009
  49. Кэйн К. и др. Детская дерматология // Цветной атлас и справочник. Пер. с англ. Под ред. О.Л. Иванова, А.Н. Львова. М.: Изд-во Панфилова; БИНОМ. Лаборатория знаний 2011
  50. Hyoger P. G. Detskaya dermatologiya. M.: Izd-vo Panfilova, 2013. [Хегер П.Г. Детская дерматология. М: Изд-во Панфилова 2013.]
  51. Cepicka W., Tielsch R. Focal infections and psoriasis vulgaris. Dematol Wochenschr 1967; (153): 193-199.
  52. Hone S.W., Donnelly M.J., Powell F., Blayney A.W. Clearance of recalcitrant psoriasis after tonsillec-tomy.Clinical Otolaryngology & Allied Sciences 1996; 21 (6): 546-547.
  53. Kataura A., Tsubota H. Clinical analyses of focus tonsil and related diseases in Japan. Acta Otolaryngol Suppl 1996; (523): 161-164.
  54. Ozawa A., Ohkido M., Haruki Y. et al. Treatmtnts of generalized pustular psoriasis: a multizenter study in Japan. J Dermatol 1999; (26): 141-149.
  55. Diluvio L., Campione E., Paterno E.J. Et al. Childhood nail psoriasis: a useful treatmet with tasaro-tene 0,05%. Pediatr Dermatol 2007; (24): 332-3.
  56. Thorleifsdottir R.H., Sigurdardottir S.L., Sigurgeirs-son В. et al. Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. J Immunol 2012; (188): 5160-5165.

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