Naftifine hydrochloride (NH) in the treatment of pityriasis versicolor

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Abstract


Introduction & objectives: The purpose of this study was to demonstrate the efficacy comparability of 1% NH lotion vs. of 1% NH cream (exoderil, Sandoz) in the treatment of pityriasis versicolor. Material & methods. 71 patients with pityriasis versicolor were randomly allocated either to receive NH lotion once daily (NH lotion group (п = 35, 38.6 years (95% CI [33,7, 43.5]) or NH cream once daily (NH cream group (п = 36, 40.8 years (95% CI [36,6, 45.0]) for 14 days. Mycological evaluations (microscopy and culture) were performed at weeks 2 and 3, inflammation symptoms evaluations were scored at day 3, weeks 2 and 3 after start of the therapy. Overall cure rates assessment included results of mycological, clinical outcomes and safety evaluation. Results. There was no difference between groups in mycological cure rates (94% vs 92%) and inflammation regression (97% vs 97%). Overall cure rate was 91% and 92% of patients in NH lotion and NH cream groups respectively (p = 0,97). Conclusion. 1% NH lotion and 1% NH cream are effective in the treatment of pityriasis versicolor.

L. P. Kotrekhova

“North-Western State Medical University named after I.I. Mechnikov”

Author for correspondence.
Email: noemail@neicon.ru

Russian Federation

A. A. Vashkevich

“North-Western State Medical University named after I.I. Mechnikov”

Email: noemail@neicon.ru

Russian Federation

E. N. Tsurupa

“North-Western State Medical University named after I.I. Mechnikov”

Email: noemail@neicon.ru

Russian Federation

P. A. Reztsova

“North-Western State Medical University named after I.I. Mechnikov”

Email: noemail@neicon.ru

Russian Federation

  1. Nematian J., Ravaghi M., Gholamrezanezhad A., Nematian E. Isolated scalp involvement with pityriasis versicolor alba (pityrias versicolor albus capitis) in a patient from a dry, temperate region. Dermatol Online J 2003; 9 (3): 17
  2. Tarazooie B., Kordbacheh P., Zaini F., Zomorodian K., Saadat f., Zeraati H., Hallaji Z., Rezaie S. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tehran, Iran. BMC Dermatol 2004; 4: 5
  3. Di Silverio A., Zeccara C., Serra F., Ubezio S., Mosca M. Pityriasis versicolor in a newborn. Mycoses 1995; 38: 227-228.
  4. Di Silverio A., Mosca M., Brandozzi G., Gatti M. Pityriasis versicolor in the aged: a clinical investigation and epidemiological survey in 190 elderly hospitalized patients. Mycopathol 1989; 105: 187-190.
  5. Muhammad N., Kamal M., Islam T., Islam N., Shafiquzzaman M. A study to evaluate the efficacy and safety of oral fluconazole in the treatment of tinea versicolor. Mymensingh Med J. 2009; 18 (1): 31-35.
  6. Burkhart C.G., Burkhart C.N., Isham N. Synergistic antimicrobial activity by combining an allylamine with benzoyl peroxide with expanded coverage against yeast and bacterial species. Br J Dermatol 2006; 154: 341-343.
  7. Rosen T., Schell B.J., Orengo I. Anti-inflammatory activity of antifungal preparations. Int J Dermatol. 1997; 36: 788-792.
  8. Климко Н.Н. микозы: диагностика и лечение. Руководство для врачей. М: Премьер МТ 2007; 336
  9. Аравийский Р.А., Климко Н.Н., Васильева Н.В. Диагностика микозов. СПб.: Издательский дом СПбМАПО 2004; 186
  10. Yoshihiro S. Malassezia Infectious Diseases. Med Mycol J 2012; 53 (1): 7-11
  11. Nakabayashi A., Sei Y., Guillot J. Identification of Malassezia species isolated from patients with seborrheic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects. Med Mycol 2000; 38: 337-341
  12. Pejkovska D., Hristova L., Nikolovska M. et al. Presence of pityriasis versicolor in dermatovenerology dispansery J. sandanski skopie. JEADV 2004; 18 supp: 2: 387-388
  13. Stanojevic M., Lestanin B., Stankovic O. Effects of fluconasol vs. topical antifungal agent in the treatment of mycotic infections. JEADV 2004; 18 supp: 2: 392-393
  14. Кубанова A.A., Потекаев Н.С., Потекаев H.H. Руководство по практической микологии. М, 2001; 144
  15. Petranyi G., Ryder N.S., Stutz A. Allylamine derivatives: New class of synthetic antifungal agents inhibiting fungal squalene epoxidase. G. Petranyi, N.S. Ryder, A.Stutz. Science 1984; 224: 1239-1243
  16. Матушевская Е.В. Свирщевская Е.В. Нафтифин в терапии грибковых инфекций кожи: 40 лет успеха. Вестн дерматол венерол 2014; (2): 72-77
  17. Gold M., Bridges T., Avakian E., Plaum S., Pappert E.J., Fleischer A.B., et al. An open-label study of naftifine hydrochloride 1% gel in the treatment of tinea versicolor. Skin Med 2011; (9): 283-286
  18. Hira S.K., Abraham M.S., Mwinga A., Kamanga J., Schmidt C. Naftifine solution (1%) in the treatment of pityriasis versicolor in Zambia. Mykosen 1986; 29 (8): 378-381
  19. Albanese G., Giorgetti P., Santagostino L. et al. Evaluation of the efficacy of a new antimycotic molecule for topical use: naftifine. G Ital Dermatol Venerol 1989; 124 (5): 33-37

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