Rationale for selecting antihistamine drugs for the therapy of chronic urticaria in terms of efficacy and safety

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Goal of the study. To compare the efficacy of antihistamine drugs for the therapy of chronic urticaria taking into consideration their effect on the patients’ cognitive functions. Materials and methods. The study involved 178 patients with chronic urticaria who were divided into six groups taking second generation antihistamine drugs: Cetirizine (n = 38), Levocetirizine (n = 27), Fexofenadine (n=26), Ebastine (n = 33), Loratadine (n = 26) and Desloratadine (n = 28). The patients recorded dynamic changes in clinical symptoms of the disease (number of urticarial components, skin itching intensity, availability or absence of urticarial derniographism, angioedema signs and signs of the shortness of breath and reduced blood pressure) in their individual diaries. Baseline signs of the patients’ cognitive condition and those recorded during the treatment were studied using the Kraepelin’s arithmetic test (modified by Schulte), I.M. Lushchikhina’s verbal and visual thinking assessment method and method for memorizing ten words. The control group comprised 31 subjects without chronic urticaria. Results of the study. Ebastine and Fexofenadine are the most efficient antihistamine drugs for the treatment of chronic urticaria. At the same time, they do not have any negative effect on the patients’ cognitive functions so they can be recommended for long-term treatment of chronic urticaria. In spite of its evident positive therapeutic effect, Cetirizine reduces mental alertness and deteriorates thinking in patients with chronic urticaria. Because of this, the drug must be prescribed with care for long-term administration to those patients whose professional activities demand increased attention concentration. Loratadine has a positive effect on the patients’ attention and thinking. However, taking into consideration its low efficacy, the drug can be prescribed as the basis therapy for the treatment of light forms of chronic urticaria.

About the authors

O. V. Skorokhodkina

Kazan State Medical University

Author for correspondence.
Email: olesya-27@rambler.ru
Russian Federation

S. V. Klyucharyova

Kazan State Medical University

Email: noemail@neicon.ru
Russian Federation


  1. Khaitov R.M., Il'ina N.I. Klinicheskie rekomendatsii. Allergologiya. Moskva: GEOTAR-Media 2008; 104-115. [Хаитов Р.М., Ильина Н.И. Клинические рекомендации. Аллергология. М: ГЭОТАР-Медиа 2008; 104-115.]
  2. Klinicheskaya allergologiya i immunologiya: ruko-vodstvo dlya praktikuyushchikh vrachey. Pod red. L.A. Goryachkinoy i K.P. Kashkina. M: Miklosh 2009; 222-272. [Клиническая аллергология и иммунология: руководство для практикующих врачей. Под ред. Л.А. Горячкиной и К.П. Кашкина. М: Миклош 2009; 222-272.]
  3. Rossiyskiy natsional'nyy soglasitel'nyy dokument «Krapivnitsa i angiootek», rekomendatsii dlya prakticheskikh vrachey. M, 2007; 126. [Российский национальный согласительный документ «Крапивница и ангиоотек», рекомендации для практических врачей. М, 2007; 126.] Литература
  4. Staubach P., Eckhardt-Henn A., Dechene M. et al. Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity. Brit J Dermatol 2006; 154: 294-298.
  5. Tataurschikova N.S. Modern aspects of use of antihistamines in therapeutic practice. Pharmateca 2011; 11: 46-50. [Татаурщикова Н.С. Современные аспекты применения антигистаминных препаратов в практике врача-терапевта. Фарматека 2011;11: 46-50.]
  6. Mikhaylov B.V., Serdyuk A.I., Fedoseev V.A. Psikhoterapiya v obshchesomaticheskoy medit-sine: Klinicheskoe rukovodstvo. Pod obshch. red. B.V. Mikhaylova. Khar'kov: Prapor, 2002; 128. [Михайлов Б.В., Сердюк А.И., Федосеев В.А. Психотерапия в общесоматической медицине: Клиническое руководство. Под общ. ред. Б.В. Михайлова. Харьков: Прапор 2002; 128.]
  7. Balin V.D., Gayda V.K., Gerbichevskiy V.K. i dr. Praktikum po obshchey, eksperimental'noy i prikladnoy psikhologii. Pod obsh red A.A. Krylova, S.A. Malicheva SPb.: Piter 2003; 506. [Балин В.Д., Гайда В.К., Гербичевский В.К. и др. Практикум по общей, экспериментальной и прикладной психологии. Под общ ред А.А. Крылова, С.А. Маличева. СПб: Питер 2003; 506.]
  8. Stolyarenko L.D. Osnovy psikhologii: praktikum. Rostov-na-Donu: Feniks 2006; 704. [Столяренко Л.Д. Основы психологии: практикум. Ростов-на-Дону: Феникс 2006; 704.]

Copyright (c) 2014 Skorokhodkina O.V., Klyucharyova S.V.

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