Preventing of transfusion syphilis

Cover Page

Abstract


Goal of the study. To study the prevalence of syphilis markers in donors in the Russian Federation, and to evaluate the effectiveness of measures to prevent blood transfusion syphilis and other bloodborne infections in the Blood Service in Russia. Materials and methods. Performance analysis of sectoral statistical surveys Russian Ministry of Health in the form number 39, «Report of the station, department of blood transfusion, hospital blood leading procurement» and the explanatory notes to them for the period from 2009 to 2013. Analysis of the results of screening donated blood for markers of syphilis. Results. It was found that the incidence of syphilis markers in donors in the whole of Russia was significantly (p < 0,05) decreased (from 0.79% in 2009 to 0.49% in 2013). However, there was heterogeneity in the proportion of donors with markers of syphilis in different regions of the Russian Federation. (From 0.68 to 0.35%). In 2013, the causative agent of syphilis markers are more often detected in donors of the North Caucasus and Siberian Federal Districts, seldom in donors in the North-Western and Urals Federal District. Hence, there remains a certain risk of transfusion transmission of syphilis. In recent years, widely implemented method viral inactivation of plasma and platelet concentrate. In 2013, the procedure viral inactivation subjected to 8% of the total issued for transfusion platelet concentrate. Conclusion. There remains a certain risk of transfusion transmission of syphilis. Further implementation of the methods of inactivation of pathogens in Blood Service of Russia will also contribute to reducing the risk of blood-borne transmission of Treponema pallidum.

A. V. Chechetkin

Russian Research Institute of Hematology and Transfusiology

Author for correspondence.
Email: vitnikcheb@mail.ru

Russian Federation

V. V. Danil’Chenko

Russian Research Institute of Hematology and Transfusiology

Email: vitnikcheb@mail.ru

Russian Federation

V. N. Chebotkevich

Russian Research Institute of Hematology and Transfusiology

Email: vitnikcheb@mail.ru

Russian Federation

A. D. Kas’Ianov

Russian Research Institute of Hematology and Transfusiology

Email: vitnikcheb@mail.ru

Russian Federation

A. B. Makeev

Russian Research Institute of Hematology and Transfusiology

Email: vitnikcheb@mail.ru

Russian Federation

V. E. Soldatenkov

Russian Research Institute of Hematology and Transfusiology

Email: vitnikcheb@mail.ru

Russian Federation

  1. Merkulova S.A. The incidence of syphilis in the Russian Federation for the period from 2000 through 2008 : main trends. Klin dermatol venerol 2009; 6: 26-30. [Иванова м.А., Лосева О.к., малыгина Н.С., Поршина О.В., меркулова С.А. заболеваемость сифилисом в Российской Федерации за период с 2000 по 2008 г.: основные тенденции. клин дерматол венерол 2009; (6): 26-30.]
  2. Borovikov V.B. STATISTICA. The art of data analysis on the computer: for professionals. 2nd ed. SPb: Piter; 2003. [Боровиков В.Б. STATISTICA. Искусство анализа данных на компьютере: Для профессионалов. 2-е изд. СПб: Питер; 2003.]
  3. Zalkind E.S. Transfusion syphilis and its prevention. NARKOMZDRAV USSR,Medgiz, Leningrad branch 1943. [залкинд Е.С. Трансфузионный сифилис и его предупреждение. НАРКОМЗДРАВ СССР, медгиз, Ленинградское отделение; 1943.]
  4. Loseva O.K. Transfusion syphilis in modern conditions. Vestn dermatol venerol 1998; 1: 14-17. [Лосева О.к. Трансфузионный сифилис в современных условиях. Вестн дерматол венерол 1998; (1): 14-17.]
  5. Orton S.L., Liu H., Dodd R.Y., Williams A.E. Prevalence of circulating Treponema pallidum DNA and RNA in blood donors with confirmed-positive syphilis tests. Transfusion 2002; 42 (1): 94-99.
  6. Chambers R.W., Foley H.T., Schmidt P.J. Transmission of syphilis by fresh blood components. Transfusion 1969; 9 (1): 32-34.
  7. Gardella C., Marfin A.A., Kahn R.H., Swint E., Markowitz L.E. Persons with Early Syphilis Identified through Blood or Plasma Donation Screening in the United States. J Infect Dis 2002; 185 (4): 545-549.
  8. Infectious Disease Testing for Blood Transfusions. NIH Consens Statement Online 1995; Jan 9-11; 13 (1): 1-29.
  9. Screening Donated Blood for Transfusion-Transmissible Infections: Recommendations. ISBN-13: 978-92-4-154788-8. Geneva: World Health Organization; 2009.
  10. Yaozhen Chen, Zhixin Liu, Qingping Zhang, Jie Chen, Wengli Sun, Jing Yi, Lingling Zhang, Peng Zhao, Long Li, Shijie Mu, Wen Yin, Xianq-ing Zhang, Xingbin Hu. Trend in prevalence of syphilis among voluntary blood donors in Xi’an, China from 2006 to 2010. Int J Infect Dis 2014; 19: 98-99.
  11. Rotanov S.V., Frigo N.V., Kubanov A.A., Vasil'eva E.L. About a serological diagnosis of syphilis in dermatovenereological institutions of the Russian Federation. Vestn dermatol venerol 2010; 5: 45-50. [Ротанов С.В., Фриго Н.В., Кубанов А.А., Васильева Е.Л. О качестве серологической диагностики сифилиса в дерматовенерологических учреждениях Российской Федерации. Вестн дерматол венерол 2010; (5): 45-50.]
  12. Van-der Sluis J.J., ten-Kate F.J., Vuzevski V.D. et al. Transfusion syphilis, survival of Trepone-mapallidum in stored donor blood. Vox Sang 1985; 49 (6): 390-399.
  13. Lin L., Dikeman R., Molini B., Lukehart S.A., Lane R., Dupuis K., Metzel P., Corash L. Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria Transfusion 2004; 44 (10): 1496-1504.

Views

Abstract - 63

PDF (Russian) - 17

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies