Phototherapy of extragenital white spot disease

Cover Page
  • Authors: Volnukhin B.A.1, Znamenskaya L.F.1, Kappusheva I.A.1, Muradyan N.L.1, Dvornikov A.S.2
  • Affiliations:
    1. State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
    2. The Russian National Research Medical University named after N.I. Pirogov (RNRMU)
  • Issue: Vol 91, No 6 (2015)
  • Pages: 61-66
  • Section: GUIDELINES FOR PRACTITIONERS
  • URL: https://www.vestnikdv.ru/jour/article/view/199
  • DOI: https://doi.org/10.25208/0042-4609-2015-91-6-61-66

Abstract


Objective. To study the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Materials and methods. Effectiveness of the phototherapy methods was studied in 12 patients with extragenital lichen sclerosus (8 women, 4 men) aged from 19 to 61 years old with the disease history of 1-25 years. 6 patients received UVA1therapy while 3 patients received general PUVA therapy and 3 patients - local PUVA therapy. All the patients underwent phototherapy in the form of monotherapy. Results. After the treatment clinical improvement was observed in 6 patients from the UVA1 group (100%) and 4 patients from the PUVA group (66.7%), significant improvement of clinical picture and clinical remission were registered in 1 (16.7%) and 2 (33.3%) patients from the PUVA group, respectively. Phototherapy caused partial or full regress of main lichen sclerosus symptoms: sclerosis, induration, erythema, epidermal atrophy and skin hypopigmentation. The tolerability of treatment was satisfying, serious adverse effects were not reported. Conclusion. Conducted research indicates the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Phototherapy may be a choice in the management of the disease.

About the authors

B. A. Volnukhin

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: volnuhin@cnikvi.ru

Russian Federation

L. F. Znamenskaya

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

I. A. Kappusheva

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

N. L. Muradyan

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

A. S. Dvornikov

The Russian National Research Medical University named after N.I. Pirogov (RNRMU)

Email: noemail@neicon.ru

Russian Federation

References

  1. Kreuter A., Wischnewski J., Terras S. et al. Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center. J Am Acad Dermatol. 2012; 67 (6): 1157-1162.
  2. Chan I., Oyama N., Neill S.M. et al. Characterization of IgG autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Clin Exp Dermatol 2004; 29 (5): 499-504.
  3. Cooper S.M., Ali I., Baldo M., Wojnarowska F. The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study. Arch Dermatol 2008;
  4. Terlou A., Santegoets L.A., van der Meijden W.I. et al. An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. J Invest Dermatol. 2012; 132 (3 Pt 1): 658-666.
  5. Kreuter A., Kryvosheyeva Y., Terras S. et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol 2013; 93 (2): 238-241.
  6. Gambichler T., Belz D., Terras S., Kreuter A. Humoral and cell-mediated autoimmunity in lichen sclerosus. Br J Dermatol 2013; 169 (1): 183-184
  7. Волнухин В.А., Мурадян Н.Л., Выборнова О.В. и др. УФА-1 терапия больных ограниченной склеродермией. Вестн дерматол венерол 2007; 6: 4-8
  8. Волнухин В.А., Самсонов В.А., Гребенюк В.Н. и др. Эффективность фотохимиотерапии больных ограниченной склеродермией. Вестн дерматол венерол 2003; 2: 9-13
  9. Kreuter A., Gambichler T., Avermaete A. et al. Low-dose ultraviolet A1 pototherapy for extragenital lichen sclerosus: results of a preliminary study. J Am Acad Dermatol 2002; 46: 251-255.
  10. Tuchinda C., Kerr H.A., Taylor C.R. et al. UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States. Photodermatol Photoimmunol Photomed 2006; 22 (5): 247-253.
  11. Rombold S., Lobisch K., Katzer K. et al. Efficacy of UVA1 phototherapy in 230 patients with various skin diseases. Photodermatol Photoimmunol Photomed 2008; 24 (1): 19-23.
  12. von Kobyletzki G., Freitag M., Hoffmann K. et al. Balneophotochemotherapie mit 8-Methoxypso-ralen bei Lichen sclerosus et atrophicus. Hautarzt 1997; 48: 488-491.
  13. Dalmau J., Baselga E., Roé E., Alomar A. Psoralen-UVA treatment for generalized prepubertal extragenital lichen sclerosus et atrophicus. J Am Acad Dermatol 2006; 55 (2 Suppl): S56-58.
  14. Струков А.И., Серов В.В. Патологическая анатомия: Учебник. 3-е изд. М: Медицина; 1993

Statistics

Views

Abstract - 251

PDF (Russian) - 191

PlumX

Dimensions


Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies