Pathomorphological changes in patients with Jessner>s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus

Cover Page

Abstract


Jessner’s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus are the group of rare, insufficiently explored dermatosis with common clinical and histological features, whose nosology is controversial today. Plasmacytoid dendritic cells play the key role in autoimmune disease induction The target of our study was the analysis of pathomorphological features of lesional skin and the research of plasmacytoid dendritic cells in the skin of patients with Jessner’s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus. Material and methods. Histological and indirect immunohistochemistry examination (anti-CD123 antibodies) of lesional skin of 36 patients was held (JLIS - 12, REM - 10, LT - 14) and 10 healthy people. Result. The main pathomorphological changes of skin in all groups were found in dermis: dense perivascular and perifollicular infiltration and deposit of mucin between collagen fibers. Deposits of mucin in papillary dermis were found between patients with JLIS, REM and LT in 10/12 (83%), 7/10 (70%) and 12/14 (86%) of cases, there were no mucin found in skin of healthy people 0/10 (0%) In all dermatosis the distribution of CD123 cells in lesional skin, in immunohistochemistry study, was corresponded clusters model of infiltrate - plasmacytoid DC concentrate in groups around vessels of superficial and profundus networks and perivascular. The comparative analysis of density and localization of perivascular infiltration, number of CD123-cells and their correspondence in dermis perivascular infiltrates didn’t reveal statistically significant differences between JLIS, REM and LT. Results. Our results allow us to consider JLIS and LT as identical decease, and REM as similar in clinical-pathomorphological features dermatosis.

About the authors

P. N. Trophymov

Federal Almazov North-West Medical Research Centre

Author for correspondence.
Email: trofimov_paul@rambler.ru

Russian Federation

O. V. Antonova

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

V. R. Khairutdinov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

I. E. Belousova

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

A. V. Samtsov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation

Email: noemail@neicon.ru

Russian Federation

References

  1. Tomasini D., Mentzel T., Hantschke M., Cerri A., Paredes B., Rutten A. et al. Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus. J Cutan Pathol 2010 Nov; 37 (11): 1132-9.
  2. Ebner S., Ehammer Z., Holzmann S. et al. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol 2004; 16: 877.
  3. Rissoan M.C., Soumelis V., Kadowki N. et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183.
  4. Cella M., Jarrossay D., Facchetti F. et al. Plasmacytoid mono- cytes migrate to inflamed lymph nodes and produce large amount of type I interferon. Nat Med 1999; 5: 919.
  5. Jessner M., Kanof B. Lymphocytic infiltration of the skin. Arch Dermatol 1953; 68: 447-9.
  6. Cerio R., Oliver G.F., Wilson Jones E., Winkelmann R.K.: The heterogeneity of Jessner's lymphocytic infiltration of the skin. J Am Acad Dermatol 1990; 23: 63-7.
  7. Lipsker D., Mitschler A., Grosshans E., Cribier B. Could Jessner's lymphocytic infiltrate of the skin be a dermal variant of lupus erythematosus? An analysis of 210 cases. Dermatology 2006; 213 (1): 15-22.
  8. Konttinen Y.T., Bergroth V., Johansson E. et al: A long-term clinicopathologic survey of patients with Jessner's lymphocytic infiltration of the skin. J Invest Dermatol 1987; 89: 205-8.
  9. Akasu R., Kahn H.J., From L.: Lymphocyte markers on formalin-fixed tissue in Jessner's lymphocytic infiltrate and lupus erythematosus. J Cutan Pathol 1992; 19: 59-65.
  10. Poenitz N., Dippel E., Klemke C.D., Qadoumi M., Goerdt S. Jessner's lymphocytic infiltration of the skin: a CD8+ polyclonal reactive skin condition. Dermatology 2003; 207 (3): 276-84.
  11. Steigleder G.K., Gartmann H., Linker U. REM syndrome: reticular erythematous mucinosis (round-cell erythematosis), a new entity? Br J Dermatol 1974; 91: 191-9.
  12. Rubegni P., Sbano P., Risulo M. et al. A case of reticular erythematous mucinosis treated with topical tacrolimus. Br J Dermatol 2004; 150: 173-4.
  13. Triffet Trevino M., Ahmed I.: Plaque-like cutaneous mucinosis (reticular erythematous mucinosis): a clinicopathologic analysis. J Cutan Pathol 1996; 23: 63.
  14. Ackerman B.A., Cavegn B.M., Abad-Casintahan F., Robinson M.J. Resolving Quandaries in Dermatology, Pathology & Dermatopathology, Vol. 1. New York: Ardor Scribendi, 1995.
  15. Gasior-Chrzan B., Husebekk A.: Reticular erythematous mucinosis syndrome: report of a case with positive immunofluorescence. J Eur Acad Dermatol Venereol 2004; 18: 375-8.
  16. Rongioletti F., Merlo V., Riva S. et al. Reticular erythematous mucinosis: a review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. Br J Dermatol 2013 Dec; 169 (6): 1207-11.
  17. Braddock S.W., Kay H.D., Maennle D. et al. Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin. J Am Acad Dermatol 1993; 28: 691-5.
  18. Marafioti T., Paterson J.C., Ballabio E. et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood 2008; 111: 3778.
  19. Lipsker D. Classification of specific cutaneous manifestations in patients with lupus erythematosus: a time for change? The concept of dermal lupus erythematosus. Dermatology 2006; 212 (4): 324-6.
  20. Toonstra J., Wildschut A., Boer J. et al. Jessner's lymphocytic infiltration of the skin. A clinical study of 100 patients. Arch Dermatol 1989; 125 (11): 1525-30.
  21. Rongioletti F., Merlo V., Riva S. et al. Reticular erythematous mucinosis: a review of patients characteristics, associated conditions, therapy and outcome in 25 cases. Br J Dermatol 2013 Dec; 169 (6): 1207-11.

Statistics

Views

Abstract - 383

PDF (Russian) - 203

PlumX

Dimensions


Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies