Treatment of superficial mycosis of glabrous skin of itraconasole

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Abstract


The treatment of fungal infections of the skin is actual problem of modern dermatology. The goal of the research. The study of the clinical efficacy, tolerance and safety of the use of the systemic antifungal drug itraconazole (Irunin) in treatment of extensive and often recidivic clinical forms of superficial mycosis of glabrous skin. Material and methods. The authors observed 56 patients aged from 18 to 60 with different clinical forms of dermatomycosis (33 - with extensive pytiriasis vesicolor, 13 - with chronic recidivic tinea pedis, 7 - with extensive mycosis of body and large flexures, 3 - with mycosis of different localizations). All patients received monotherapy of itraconazole (Irunin): two capsules (200 mg) once a day for 7 days, then one capsule (100 mg) once a day for 14 days. The duration of the treatment was 21 days. Results. Clinical and mycological recovery was achieved in all number of the cases. Serious unnecessary effects of treatment was not observed. Conclusions. The results of the study have shown high therapeutic efficacy and good tolerability of antifungal drug itraconazole (Irunin) in the systemic treatment of fungal infections of the skin.

M. A. Tarasova

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary

Author for correspondence.
Email: noemail@neicon.ru

Russian Federation

E. A. Ermoshina

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary

Email: EAErmoshina@mail.ru

Russian Federation

I. V. Nagornova

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary

Email: noemail@neicon.ru

Russian Federation

S. V. Stepanova

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary

Email: noemail@neicon.ru

Russian Federation

  1. Potekaev N.N., Korsunskaya I.M., Serov N.D. Mycoses in Russia: epidemiology, clinical features, treatment with russian antimycotics. Clinical Dermatology and Venerology 2006; (3): 92-95.
  2. Burzykowski T., Molenberghs G., Abeck D. High prevalence of foot diseases in Europe: results of Achilles Project. Mycoses 2003; 46 (11-12): 496-505.
  3. Martin E.S., Elewski B.E. Cutaneous fungal infections in the elderly. Clin Geriatr Med 2002; 18: 59-75.
  4. Sokolova T.V., Maliarchuk A.P., Maliarchuk T.A. Clinical and epidemiological monitoring superficial skin mycoses in different regions of the Russian Federation. Clinical Dermatology and Venerology 2011; (4): 55-64.
  5. Kotrekhova L.P., Raznatovskij K.I. Etiology, clinic, treatment of dermatomycoses in patients with diabetes mellitus. Problems in medical mycology 2005; (7): 13-18.
  6. Lykova S.G., Nemchaninova O.B., Petrenko O.S. Dermatologic aspects of metabolic syndrome. Clinical Dermatology and Venerology 2006; (4): 74-76.
  7. Gudkova Yu.I., Kotrekhova L.P., Raznatovsky K.I. Dermatomycoses and skin appendages - nails, hairs in patients receiving long - term systemic glucocorticosteroid therapy. Problems in medical mycology 2006; 8: 5-11.
  8. Kotrekhova L.P., Raznatovskiy K.I., Vashkevich A.A. Osobennosti techeniya mikozov kozhi na sovremennom etape i ikh ratsional'naya terapiya. Consilium Medicum. Dermatovenerologiya 2014; (1): 30-34.
  9. Klinicheskie rekomendatsii RODV “Dermatovenerologiya”. Pod red. A.A. Kubanovoy. M: DEKS-PRESS; 2010; 435.
  10. Stepanova Zh.V. Gribkovye zabolevaniya: diagnostika i lechenie. M.: Miklosh, 2005; 124.
  11. Sergeev A.Yu., Sergeev Yu.V. Gribkovye infektsii. Rukovodstvo dlya vrachey. 2-e izd. M: BinomPress, 2008; 480.
  12. Heykants J., Van Peer A., Van de Velde V. et al. The clinical pharmacokinetics of itraconazole: an overview. Mycoses 1989; 32: Suppl 1: 67-87.
  13. Stepanova Zh.V., Skripkin Yu.K. Terapevticheskaya effektivnost' orungala (itrakonazola) pri dermatofitiyakh i kandidoze. Vestn Dermatol Venerol 1998; (4): 56-58.
  14. Mikeshina A.V., Galimzyanova R.M. Klinicheskiy opyt primeneniya orungala (itrakonazola). Vestn Dermatol Venerol 2000; (2): 44-46.
  15. Del Rosso J.Q. Treatment of onychomycosis and tinea pedis with intermittent itraconazole therapy. J Am Ostepath Ass 1996; 96: 607-609.

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