Naftifine hydrochloride in treatment of foot mycosis complicated with a bacterial infection and significant inflammatory reaction

Cover Page

Abstract


Goal of the study. To compare the etticacy ot nattitine hydrochloride (Exoderil® cream) and combination cream comprising betamethasone dipropionate, clotrimazole and gentamicin sultate in treatment ot toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. Materials and methods. A single-center, prospective, randomized, open-label comparative study involved 75 patients aged 23-80 suttering trom toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. The patients were randomized in two groups. The tirst group comprised 36 patients receiving nattitine hydrochloride while the second one included 39 patients treated with a combination drug comprising betamethasone, clotrimazole and gentamicin. Results. The anti-bacterial etticacy ot nattitine and combination drug comprising betamethasone, clotrimazole and gentamicin was comparable. Complete sanitation ot the bacterial intection was achieved in 94% ot the patients in both groups. The antimycotic etticacy ot nattitine (Exoderil® cream) was reliably higher than that ot the three-component drug to amount to 97% and 82%, respectively (p = 0.03). Complete recovery was achieved in 92% ot the patients treated with nattitine hydrochloride cream and 82% ot the patients treated with the three-component drug (p = 0.22). Conclusion. Exoderil® cream (active substance: nattitine) is a highly etticient drug tor treatment ot ditterent clinical torms ot skin mycosis including those accompanied by a signiticant intlammatory reaction and/or concomitant bacterial intection.

L. P. Kotrekhova

North-Western State Medical University named atter I.I. Mechnikov

Author for correspondence.
Email: zurupalubov@inbox.ru

Russian Federation

  1. Rukavishnikova V.M. Mikozy stop M. 1999; 317. [Рукавишникова В.М. Микозы стоп М, 1999; 317.]
  2. Robbins C.M. Tinea pedis. eMedicine. 2007. Available at: http://www.emedicine.com/DERM/ topic470.htm. Accessed October 8, 2007.
  3. Khismatulina I.M., Abdurakhmanov R.M., Lisovskaya S.A. i dr. Perspektivy ispol'zovaniya modifitsirovannykh prirodnykh terpenoidov kak lekarstvennykh sredstv novogo tipa v lechenii i profilaktike gribkovykh zabolevaniy kozhi. Vestn posledipl med obraz 2008; 2: 34-38. [Хисматулина И.М., Абдурахманов Р.М., Лисовская С.А. и др. Перспективы использования модифицированных природных терпеноидов как лекарственных средств нового типа в лечении и профилактике грибковых заболеваний кожи. Вест последипл мед образ 2008; (2): 34-38.]
  4. Sergeev Yu.V., Kudryavtseva E.V., Sergeev A.Yu. «Ekzoderil» (naftifin) - klinicheskaya effektivnost' pri dermatomikozakh i infektsiyakh smeshannoy etiologii. Ros zhurn kozh i ven bol 2004; 1: 42-43. [Сергеев Ю.В., Кудрявцева Е.В., Сергеев А.Ю. «Экзодерил» (нафтифин) - клиническая эффективность при дерматомикозах и инфекциях смешанной этиологии. Рос журн кож венерич бол 2004; (1): 42-43.] Литература
  5. Burkhart C.G., Burkhart C.N., Isham N. Synergistic antimicrobial activity by combining an allylamine with benzoyl peroxide with expanded coverage against yeast and bacterial species. Br J Dermatol 2006; 154: 341-343.
  6. Rosen T., Schell B.J., Orengo I. Anti-inflammatory activity of antifungal preparations. Int J Dermatol 1997; 36: 788-792.
  7. Klimko N.N. Mikozy: diagnostika i lechenie. Rukovodstvo dlya vrachey. M: Prem'er MT, 2007; 336. [Климко Н.Н. Микозы: диагностика и лечение. Руководство для врачей. М: Премьер МТ, 2007; 336.]
  8. Kubanova A.A., Potekaev N.S., Potekaev N.N. Rukovodstvo po prakticheskoy mikologii. M, 2001; 144. [Кубанова A.A., Потекаев Н.С., Потекаев H.H. Руководство по практической микологии. М, 2001; 144.]
  9. Petranyi G., Ryder N.S., Stutz A. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 1984; 224 (4654): 1239-1241.
  10. Steinhilber D., Jaschonek K., Knospe J. et al. Effects of novel antifungal azole derivatives on the 5-lipoxygenase and cyclooxygenase pathways. Drug Res 1990; 40: 1260-1262.
  11. Choi T.S., Solomon B., Nowakowski M. et al. Effect of naftifine on neutrophil adhesion. Skin Pharmacol 1996; 9 (3): 190-193.
  12. Tronnier H. Inflammatory dermatomycoses - comparative study of Naftifine and a combination of a corticosteroid and an imidazole derivative. Mycosen 1987; 30 (suppl. 1): 78-87.
  13. Smith E.B., Breneman D.L. Griffith R.F. et al. Double-blind comparison of naftifine cream and clotrimazole/betametasone dipropionate cream in the treatment of tinea pedis. J Am Acad Dermatol 1992; 26; 125-127.
  14. Nolting S. Investigation of the antibacterial effect of the fungal agent naftifine - "Left versus right" clinical comparative study between naftifine and gentamycin in pyoderma. Mycosen 1987; 30 (Suppl 1): 124-128.

Views

Abstract - 121

PDF (Russian) - 27

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies