Application of external drugs comprising silver compounds for the treatment of pyodermic patients

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Abstract


An external anti-bacterial therapy is selected for pyodermic patients empirically. Silver sulfathiazole has an evident anti-inflammatory and anti-microbial effect against a broad range of microorganisms. Goal of the study. To assess the efficacy, safety and tolerability of a cream comprising 2% silver sulfathiazole vs. 3% tetracycline ointment for the treatment of pyodermic patients. Materials and methods. The study involved 50 pyodermic patients (at the mean age of 23.5 ± 4.1 years) including 31 (62%) male and 19 (38%) female patients. The patients were divided into two groups: Group I (n = 35) used the cream comprising 2% silver sulfathiazole while Group II (n = 15) was administered 3% tetracycline ointment. All of the patients were assessed for clinical and microbiological efficacy of the therapy. Results. The average patient recovery time in Group I amounted to 8.7 ± 0.9 days and 13.1 ± 2.7 days in Group II (р < 0.01). As many as 33 patients (94.3%) achieved clinical recovery and 2 patients (5.7%) achieved improvement by Day 10 in Group I; in Group II, clinical recovery was observed in 8 patients (53.3%), improvement - in 3 patients (20%), and no effect - in 4 patients (26.7%). Conclusion. The external anti-bacterial monotherapy of pyodermic patients with the cream comprising 2% silver sulfathiazole is more efficient than treatment with 3% tetracycline ointment. High clinical and microbiological efficacy of the cream comprising 2% silver sulfathiazole makes it possible to recommend it for empirical treatment of pyodermic patients.

A. V. Samtsov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika

Author for correspondence.
Email: avsamtsov@mail.ru

Russian Federation

I. N. Telichko

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika

Email: noemail@neicon.ru

Russian Federation

A. V. Statsenko

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika

Email: noemail@neicon.ru

Russian Federation

V. R. Khairutdinov

Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika

Email: noemail@neicon.ru

Russian Federation

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