Microbial eczema: up-to-date topical treatment with silver sulfathiazole

Cover Page

Abstract


Goal. The authors conducted a comparative assessment of the efficacy and safety of 2% silver sulfathiazole in a prospective parallel-group observational study of patients with microbial eczema at the exacerbation stage. Materials and methods. The efficacy of the therapy was assessed on Day 7 and Day 14 based on dynamic calculations of the EASI index and ultrasonic assessment of the intensity of pathological processes in the epidermis and derma; the life quality was assessed based on DLQI and EQ-5D indices, respectively. The microbial composition in the lesions was assessed based on bacterioscopy tests of the contents of blains and erosion fluids. The safety of the therapy was assessed based on the frequency of adverse effects. Results. The administration of 2% silver sulfathiazole arrested both eczematous and pyogenic processes in the lesions within a short period of time, which was confirmed by ultrasonic tests: the depth and density of epidermis and derma were normalized. When applications were performed twice a day, the efficacy with regard to gram-positive bacteria was higher as compared to “classical” topical antibiotics. An evident therapeutic effect with regard to gram-positive bacteria and absence of adverse effects substantially improved the life quality of patients suffering from microbial eczema.

About the authors

A. L. Bakulev

Saratov State Medical University named after V.I. Razumovsky

Author for correspondence.
Email: al_ba05@mail.ru

Russian Federation

S. S. Kravchenya

Saratov State Medical University named after V.I. Razumovsky

Email: noemail@neicon.ru

Russian Federation

A. N. Platonova

Saratov State Medical University named after V.I. Razumovsky

Email: noemail@neicon.ru

Russian Federation

References

  1. Znamenskaja L.F., Jakovleva S.V. Disturbance of the epidermal barrier and ways of its correction. Vestn Dermatol Venerol 2009; 4: 85-87. [
  2. Adrian M. Goldstein et al. Ceramides and the stratum corneum: structure, function and the new models to promote repair. Internat. J Dermat 2003; 42 (3): 256-259.
  3. Nardo A.D. et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-venerol 1998; 78 (1): 27-30.
  4. Korsunskaya I.M., Tamrazova O.B., Sorkina I.L., Nevozinskaya Z.A. Treatment of bacterial diseases of skin at children. Practice of the pediatrician 2010; 3: 40-43.
  5. Samtsov A.V., Telichko I.N., Statsenko A.V. et al. Application of external drugs comprising silver compounds for the treatment of pyodermic patients. Vestn Dermatol Venerol 2014; 1: 75-80
  6. Voboril R., Weberova J., Kralove H. Successful treatment of vascular prosthetic grafts in the groin using conservative therapy with povidoneiodine solution. Ann Vase Surg 2004; 18 (3): 372-75.
  7. Matushevskaya Y.V. Antibacterial drugs in the form of sprays for the topical treatment of pyodermas and dermatoses complicated with a secondary infection. Vestn Dermatol Venerol 2014; 2: 60-63.
  8. European Task Force on Atopic dermatitis Position paper on diagnosis and treatment of atopic dermatitis; 2005.
  9. Kubanova A. A., Bakulev A.L., Zaslavsky D.V. et al. Clinical recommendations of RODV. Atopic dermatitis, Moscow 2010; 40.
  10. Blume-Peytavi U., Metz M. Atopic dermatitis in children: management of pruritis. J EurAcadDermatolVenerol 2012; 26 (6): 2-8.
  11. Kalamkaryan A.A., Arhangelskaja E.I., Gluhenkij B.T. Gnoinichkovye zabolevania koshi. Koshnye I venericheskie bolezni. Moskva: Medicina 1995; 1: 256-94.
  12. Lansdown A.B. Silver in health care: antimicrobial effects and safety in use. Current Problems in Dermatology 2006; 33: 17-34.
  13. Margraf H.W., Covey T.H. A trial of silver-zincallantoinate in treatment of leg ulcers. Archives of Surgery 1977; 112 (6): 699-704.

Statistics

Views

Abstract - 256

PDF (Russian) - 302

PlumX

Dimensions


Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies