Email this article 
Skin lesion at acute monoblastic leukemia (clinical observation)
- Authors: Chernova N.G.1, Sinicyna M.N.1, Dvirnyk V.N.1, Kovrigina A.M.1, Zvonkov E.E.1, Parovichnikova E.N.1
-
Affiliations:
- Hematological Scientific Center
- Issue: Vol 93, No 1 (2017)
- Pages: 46-50
- Section: CLINICAL CASE REPORTS
- URL: https://vestnikdv.ru/jour/article/view/296
- DOI: https://doi.org/10.25208/0042-4609-2017-93-1-46-50
- ID: 296
Cite item
Full Text
Abstract
At present diagnosis of acute leukemia does not represent any difficulties and is based on morphological and immunophenotypical bone marrow studies. The paper presents a non-standard verification algorithm of acute monoblastic leukemia in elderly female patient, with leukemic skin lesion. Morphologic and immunohistochemical studies of biopsy materials of skin, lymph node and bone marrow allow establishing a linear membership of tumor cells and promptly verifying the diagnosis of leukemia. Lack of the overall clinical examination in such cases leads to diagnostic errors and to late verification of the true diagnosis and significantly worsens the prognosis.
About the authors
N. G. Chernova
Hematological Scientific Center
Author for correspondence.
Email: ngchernova@mail.ru
Russian Federation
M. N. Sinicyna
Hematological Scientific Center
Email: noemail@neicon.ru
Russian Federation
V. N. Dvirnyk
Hematological Scientific Center
Email: noemail@neicon.ru
Russian Federation
A. M. Kovrigina
Hematological Scientific Center
Email: noemail@neicon.ru
Russian Federation
E. E. Zvonkov
Hematological Scientific Center
Email: noemail@neicon.ru
Russian Federation
E. N. Parovichnikova
Hematological Scientific Center
Email: noemail@neicon.ru
Russian Federation
References
- Swerdlow S. H., Campo E., Harris N. L., Jaffe E. S., Pileri S. A., Stein H., Thiele J., Vardiman J. W. WHO classification of tumor of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.
- Savchenko V. G., Parovichnikova E. N., Afanasyev B. V., Gritsayev S. V., Semochkin S. V., Bondarenko S. N., Troitskaya V. V., Sokolov A. N., Kuzmina L. A., Klyasova G. A., Gaponova T. V., Baranova O.Yu., Lapin V. A., Konstantinova T. S., Samoylova O. S., Kaporskaya T. S., Shatokhin S. V. Natsionalnyye klinicheskiye rekomendatsii po diagnostike i lecheniyu ostrykh miyeloidnykh leykozov vzroslykh. Gematologiya i transfuziologiya. 2014. T. 59. N S2. S. 2-29. [Савченко В. Г., Паровичникова Е. Н., Афанасьев Б. В., Грицаев С. В., Семочкин С. В., Бондаренко С. Н., Троицкая В. В., Соколов А. Н., Кузьмина Л. А., Клясова Г. А., Гапонова Т. В., Баранова О. Ю., Лапин В. А., Константинова Т. С., Самойлова О. С., Капорская Т. С., Шатохин С. В. Национальные клинические рекомендации по диагностике и лечению острых миелоидных лейкозов взрослых. Гематология и трансфузиология. 2014. Т. 59. N S2. С. 2-29]
- Cho-Vega J. H., Medeiros L. J., Prieto V. G., Vega F. Leukemia cutis Am J Clin Pathol. 2008 Jan;129(1):130-42. doi: 10.1309/WYACYWF-6NGM3WBRT.
- Chang H., Brandwein J., Yi Q. L., Chun K., Patterson B., Brien B. Extramedullary infiltrates of AML areassociated with CD56 expression, 11q23 abnormalites and inferior clinical outcome. Leuk Res. 2004 Oct; 28(10):1007-11. doi: 10.1016/j.leukres.2004.01.006.
- Agis H., Weltermann A., Fonatsch C., Haas O., Mitterbauer G., Mullauer L., Schrei-ber S., Schwarzinger I., Juretzka W., Valent P., Jager U., Lechner K., Geissler K. A comparative study on demographic, histological and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis. Ann Hematol 2002 Feb; 81(2): 90- 5. doi: 10.1007/s00277-001-0412-9.
- Rukavitsyn A. O., Lamotkin I. A., Antipova A. S. Kharakteristika spetsificheskikh porazheniy kozhi pri ostrykh leykozakh. Gematologiya. Transfuziologiya. Vostochnaya Evropa. № 2 (02). 2015. S. 135-141. [Рукавицын А. О., Ламоткин И. А., Антипова А. С. Характеристика специфических поражений кожи при острых лейкозах. Гематология. Трансфузиология. Восточная Европа. № 2 (02). 2015. С. 135-141.]
- Long J. C., Mihm M. C. Multiple granulocytic tumors of the skin: report of six cases of myelogenous leukemia with initial manifestations in the skin. Cancer 1977 May; 39 (5): 2004-16.
- Faaij C. M., Willemze A. J., Revesz T., et al. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7. Pediatr Blood Cancer 2010:55; 344-348. doi: 10.1002/pbc.22500.
- Sharma S. K, Gupta S., Seth T., Mishra P., Mahapatra M., Singh M. K., Gupta S. Leukemia Cutis: An Unusual Presentation Indian J Hematol Blood Transfus. Sep 2012; 28 (3): 175-177. doi: 10.1007/s12288-011-0113-z.
- Martinez-Escaname M., Zuriel D., Tee S. I., Fried I., Massone C., Cerroni L. Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses. Am J Dermatopathol 2013 Jun; 35 (4): 419-24. doi: 10.1097/DAD.0b013e31826ffe6f.
- Kaddu S., Zenahlik P., Beham-Schmid C., Kerl H., Cerroni L. Specific cutaneous infiltrates in patients with myelogenous leukemia: A clini-copathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 1999 Jun; 40 (6 Pt 1): 966-78.
- Byrd J. C., Weiss R. B., Arthur D. C., Lawrence D., Baer M. R., Davey F., Trikha E. S., Carroll A. J., Tantravahi R., Qumsiyeh M., Patil S. R., Moore J. O., Mayer R. J., Schiffer C. A., Bloomfield C. D. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. J Clin Oncol 1997 Feb; 15 (2): 466-75.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).